SCHEMBL1083102

SCHEMBL1083102

O=[N+]([O-])c1ccc(COc2cccc3cccnc23)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 1.00
KMT2A Q03164 6/20 1.00
NPC1 O15118 3/20 1.00
RAB9A P51151 3/20 0.66
MAPT P10636 6/20 0.58
ALDH1A1 P00352 4/20 0.58
KDM4E B2RXH2 3/20 0.58
HDAC6 Q9UBN7 1/20 0.58
GAA P10253 1/20 0.58
MAPK1 P28482 1/20 0.58
HTT P42858 1/20 0.58
NPSR1 Q6W5P4 2/20 0.56
L3MBTL1 Q9Y468 1/20 0.56
LMNA P02545 2/20 0.55
SMN1; SMN2 Q16637 1/20 0.53
POLB P06746 1/20 0.53
PPIF P30405 1/20 0.51
PPIA P62937 1/20 0.51
NFKBIA P25963 1/20 0.50
RELA Q04206 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9447009 0.87 KMT2A (0.77) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL9951450 0.83 MEN1 (0.78) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL3891777 0.81 MEN1 (0.68) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL6027132 0.80 NPC1 (0.77) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL6021122 0.80 NPC1 (1.00) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL24430062 0.80 NPC1 (0.77) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL29360828 0.79 NPC1 (0.77) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL1101199 0.79 NPC1 (0.77) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL9687632 0.79 MAPT (0.67) MEN1KMT2ANPC1RAB9AMAPT
SCHEMBL5865429 0.79 MAPT (0.71) MEN1KMT2ANPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140256960-A1 GENE EXPRESSION CASSETTE AND A TRANSFORMANT, AND A METHOD FOR MANUFACTURING 2-DEOXY-SCYLLO-INOSOSE AND A METHOD FOR PURIFYING 2-DEOXY-SCYLLO-INOSOSE USING SAID TRANSFORMANT MITSUI CHEMICALS, INC. (JP) 2014-09-11 US disclosed
US-8758741-B2 Gene expression cassette and a transformant, and a method for manufacturing 2-deoxy-scyllo-inosose and a method for purifying 2-deoxy-scyllo-inosose using said transformant MITSUI CHEMICALS, INC. (JP) 2014-06-24 US disclosed
CN-101151368-B Gene expression cassette and transformant, and process for production of 2-deoxy-scyllo-inosose and process for purification of 2-deoxy-scyllo-inosose using the transformant NIIGATA BIO RES CT INC 2011-06-15 CN disclosed
EP-1865056-B1 GENE EXPRESSION CASSETTE AND TRANSFORMANT, AND PROCESS FOR PRODUCTION OF 2-DEOXY-SCYLLO-INOSOSE AND PROCESS FOR PURIFICATION OF 2-DEOXY-SCYLLO-INOSOSE USING THE TRANSFORMANT NIIGATA BIO RES PARK INC (JP) 2011-01-26 EP disclosed
US-20100015672-A1 Gene Expression Cassette and a Transformant, and a Method for Manufacturing 2-Deoxy-Scyllo-Inosose and a Method for Purifying 2-Deoxy-Scyllo-Inosose Using Said Transformant NIIGATA BIO-RESEARCH CENTER, INC. (JP) 2010-01-21 US disclosed
CN-101151368-A Gene expression cassette and transformant, and process for production of 2-deoxy-scyllo-inosose and process for purification of 2-deoxy-scyllo-inosose using the transformant NIIGATA BIO RES CT INC (JP) 2008-03-26 CN disclosed
EP-1865056-A1 GENE EXPRESSION CASSETTE AND TRANSFORMANT, AND PROCESS FOR PRODUCTION OF 2-DEOXY-SCYLLO-INOSOSE AND PROCESS FOR PURIFICATION OF 2-DEOXY-SCYLLO-INOSOSE USING THE TRANSFORMANT Niigata Bio-Research Center, Inc. (JP) 2007-12-12 EP disclosed
EP-1266887-B1 Indenoindoline derivatives, their process of preparation and pharmaceutical compositions containing them SERVIER LAB (FR) 2005-08-17 EP disclosed
CN-1156446-C Indenoindolone compounds, their preparation and medicinal compositions containing them ɪά��ʵ���� 2004-07-07 CN disclosed
CN-1390834-A Indenoindolone compounds, their preparation and medicinal compositions containing them SEUVILE LAB (FR) 2003-01-15 CN disclosed
US-6380223-B1 FOR THERAPY OF DISEASES, SUCH AS OBESITY, DIABETES, INFLAMMATION PFIZER INC. 2002-04-30 US disclosed