Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.44 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.44 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9836689 | 0.85 | CRBN (0.49) | CRBNHTR1AOPRK1 | |
| SCHEMBL9294186 | 0.85 | MEN1 (0.47) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9377064 | 0.83 | NPC1 (0.44) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL28167777 | 0.83 | CRBN (0.47) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL27306350 | 0.80 | ADRB2 (0.40) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7348087 | 0.80 | NPC1 (0.41) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL14784833 | 0.79 | TSHR (0.50) | ADRB2ADRB1HTR1AOPRK1BRD4 | |
| SCHEMBL18707892 | 0.78 | ADRB2 (0.39) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10569911 | 0.76 | ADRB2 (0.50) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL24348808 | 0.76 | CRBN (0.45) | CRBNBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4619932-A | CENTRAL NERVOUS SYSTEM CONTROLLERS; ANTI-SCHIZOPHRENIA AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-28 | — | — | US | disclosed |
| US-4567187-A | CENTRAL NERVOUS SYSTEM | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-28 | — | — | US | disclosed |
| US-4460593-A | Carbostyril derivatives, and central nervous system controlling agents containing the carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-07-17 | — | — | US | disclosed |
| US-4455422-A | ANTIHISTAMINES, CNS CONTROLLERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-19 | — | — | US | disclosed |