SCHEMBL108376

SCHEMBL108376

Cc1cc(C)c(N)c(C(=O)O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 1.00
GABRP O00591 2/20 0.46
GABRD O14764 2/20 0.46
GABRA1 P14867 2/20 0.46
GABRB1 P18505 2/20 0.46
GABRG2 P18507 2/20 0.46
GABRB3 P28472 2/20 0.46
GABRA5 P31644 2/20 0.46
GABRA3 P34903 2/20 0.46
GABRA2 P47869 2/20 0.46
GABRB2 P47870 2/20 0.46
GABRA4 P48169 2/20 0.46
GABRE P78334 2/20 0.46
GABRA6 Q16445 2/20 0.46
GABRG1 Q8N1C3 2/20 0.46
GABRG3 Q99928 2/20 0.46
GABRQ Q9UN88 2/20 0.46
CSNK2A1 P68400 1/20 0.45
KMT2A Q03164 2/20 0.44
MEN1 O00255 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29502911 1.00 KDM4E (1.00) KDM4EGABRPGABRDGABRA1GABRB1
SCHEMBL11881146 0.89 KDM4E (0.79) KDM4EGABRPGABRDGABRA1GABRB1
SCHEMBL1553215 0.83 KDM4E (0.70) KDM4EGABRPGABRDGABRA1GABRB1
SCHEMBL2060597 0.83 KDM4E (0.70) KDM4ETDP1GAAALDH1A1LMNA
SCHEMBL2771019 0.83 KDM4E (0.70) KDM4ETDP1GAAALDH1A1LMNA
SCHEMBL5424439 0.83 KDM4E (0.70) KDM4EGABRPGABRDGABRA1GABRB1
Hydrochloric Acid SCHEMBL5430842 0.81 KDM4E (0.68) KDM4EGABRPGABRDGABRA1GABRB1
SCHEMBL6120291 0.81 KDM4E (0.68) KDM4EGABRPGABRDGABRA1GABRB1
SCHEMBL7038599 0.81 KDM4E (0.68) KDM4EGABRPGABRDGABRA1GABRB1
SCHEMBL10932482 0.81 KDM4E (0.68) KDM4EGABRPGABRDGABRA1GABRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 282 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010671-B One-step synthesis method of 2-substituted quinazolinone 江苏大学 2023-10-10 CN claimed
CN-115010671-A One-step synthesis method of 2-substituted quinazolinone 江苏大学 2022-09-06 CN claimed
CN-114836507-A Screening method and application of amino acid degradation product with induction activity 华南理工大学 2022-08-02 CN claimed
CN-114702671-A Carboxylated crosslinked polyimide prepolymer and preparation method thereof 江苏环峰电工材料有限公司 2022-07-05 CN claimed
CN-110551280-B Liquid crystal polymer, preparation method thereof and flexible printed circuit board prepared from liquid crystal polymer Nanjing Qingyan Polymer New Materials Co.,Ltd. (CN) 2021-08-31 CN claimed
CN-110551280-A Liquid crystal polymer, preparation method thereof and flexible printed circuit board prepared from liquid crystal polymer NANJING QINGYAN POLYMER NEW MAT CO LTD 2019-12-10 CN claimed
CN-106381026-B A kind of high-hardness, wearable acrylic ester aquosity paint 安徽省金盾涂料有限责任公司 2018-12-14 CN claimed
CN-106381026-A High-hardness and high-wear-resistance acrylate water-based paint 安徽省金盾涂料有限责任公司 2017-02-08 CN claimed
CN-106366899-A High-wear-resistant antibacterial acrylate paint 安徽省金盾涂料有限责任公司 2017-02-01 CN claimed
CN-104341370-A Preparation method of cetilistat SHANDONG CHUANGXIN PHARMACEUTICAL RES AND DEV CO LTD 2015-02-11 CN claimed
WO-2008130924-A2 ISOTOPICALLY-LABELED GLYCANS MOMENTA PHARMACEUTICALS, INC. (US) 2008-10-30 WO claimed
EP-0654659-B1 Defined volume test device BOEHRINGER MANNHEIM CORP (US) 1997-02-12 EP claimed
EP-0345781-B1 Defined volume test device BOEHRINGER MANNHEIM CORP (US) 1995-08-30 EP claimed
EP-0654659-A1 Defined volume test device BOEHRINGER MANNHEIM CORPORATION (US) 1995-05-24 EP claimed
US-4994238-A Constant volume chemical analysis test device ROCHE DIABETES CARE, INC. 1991-02-19 US claimed
EP-0345781-A2 Defined volume test device BOEHRINGER MANNHEIM CORPORATION (US) 1989-12-13 EP claimed
US-20250171452-A1 TRYPTANTHRIN DERIVATIVES AND USES THEREOF VISCIENT BIO, INC. 2025-05-29 US disclosed
EP-4514804-A1 TRYPTANTHRIN DERIVATIVES AND USES THEREOF Viscient Bio, Inc. (US) 2025-03-05 EP disclosed
US-4087606-A ANTIALLERGENS AMERICAN HOME PRODUCTS CORPORATION (US) 1978-05-02 US disclosed
US-4054591-A ANTIALLERGIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1977-10-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250171452-A1 TRYPTANTHRIN DERIVATIVES AND USES THEREOF IDO2, IDO1, TPSB2 KDM4E 1128/4885GABRP 3537/4885GABRD 4100/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.