TPSB2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16396431	0.77	10/20
SCHEMBL16396341	0.66	10/20
SCHEMBL16396359	0.65	10/20
SCHEMBL16396439	0.62	10/20
SCHEMBL16396345	1.00	9/20
SCHEMBL16396356	1.00	9/20
SCHEMBL16396421	1.00	9/20
SCHEMBL16396675	1.00	9/20
SCHEMBL16396817	1.00	9/20
SCHEMBL16396877	1.00	9/20
SCHEMBL16396087	0.86	9/20
SCHEMBL16396636	0.83	9/20
SCHEMBL16396493	0.83	9/20
SCHEMBL16396848	0.83	9/20
SCHEMBL16396860	0.83	9/20
SCHEMBL16396866	0.82	9/20
SCHEMBL16396854	0.82	9/20
SCHEMBL16396839	0.81	9/20
SCHEMBL16396841	0.81	9/20
SCHEMBL16396422	0.81	9/20

Clinical trials — most relevant to TPSB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Imatinib in KIT-negative Systemic Mastocytosis	PHASE4	COMPLETED
Effect of Montelukast in Preventing Dengue With Warning Signs in Dengue Patients	PHASE2/PHASE3	COMPLETED
Effects of Anti-TSLP in Patients With Asthma	PHASE2	COMPLETED
A Randomized, Double-Blind, Placebo-Controlled Study of Omalizumab for Idiopathic Anaphylaxis	PHASE2	COMPLETED
The Safety of Administering a Second Dose of a COVID-19 mRNA Vaccine in Individuals Who Experienced a Systemic Allergic Reaction to an Initial Dose	PHASE2	COMPLETED
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK002	PHASE1	COMPLETED
Investigation of the Frequency of Hereditary Hyper Alpha-tryptasemia in Patients With Elevated Basal Tryptasemia	nan	ACTIVE_NOT_RECRUITING
Dosage of Serum Tryptase Levels in a Population of Premature Newborns to Evaluate Mast Cell Activity	nan	COMPLETED
Role of Tryptase Levels in Patients With Stable Coronary Artery Disease.	nan	RECRUITING
Tryptase Level as a Marker of Complications in Transcatheter Aortic Valve Replacement	nan	UNKNOWN
Tryptase and Coronary Heart Disease	nan	COMPLETED
Serum Basal Tryptase Levels in Healthy Children	nan	COMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Diagnosis and Allergen Identification of Perioperative Anaphylaxis	nan	RECRUITING
Persistence of Sensitization to Contrast Media	nan	NOT_YET_RECRUITING
Kinetics of Nasal Cytokine Responses to Mechanical Stimulation	nan	COMPLETED
Perioperative Anaphylaxis in Patients Attending University Hospitals (Egypt - UK).	nan	COMPLETED
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing	nan	COMPLETED
The Utility of Serum Tryptase in the Diagnosis of Shrimp- Induced Anaphylaxis	nan	COMPLETED
GI Alpha-Gal Study	nan	COMPLETED
Perioperative Hypersensitivity in Children	nan	COMPLETED
Are Mast Cells Involved in Autoinflammatory Diseases	nan	NOT_YET_RECRUITING
Serum Tryptase Levels During Cardiac Surgery, Diagnosis and Treatment Decisions for Allergic Reactions	nan	COMPLETED
Mucosal IgE to Improve Diagnosis of Food Allergy and Food Hypersensitivity	nan	RECRUITING
Pathogenesis of Physical Induced Urticarial Syndromes	nan	COMPLETED
Cytokine Production Patterns in Patients With Systemic Mastocytosis Compared With Atopic Dermatitis and Healthy Individuals	nan	COMPLETED
Study of Factors Regulating Mast Cell Proliferation	nan	RECRUITING
Mast Cells and Its Proteases in COPD	nan	UNKNOWN
Screening Study for KIT D816V Mutated Mast Cell Disease in Select Populations	nan	RECRUITING
In Vivo Assessment of Histamine Pharmacodynamics	nan	WITHDRAWN

Related proteins — ESM-2 sequence neighbours (a TPSB2 binder may also engage these)

Protein	Name	Similarity
TPSAB1	Tryptase beta-1	1.000	landscape →
P27435	—	0.996	P27435 →
P50342	—	0.994	P50342 →
Q02844	—	0.994	Q02844 →
P21845	—	0.994	P21845 →
Q9XSM2	—	0.993	Q9XSM2 →
P50343	—	0.992	P50343 →
Q99MS4	—	0.988	Q99MS4 →
Q8BJR6	—	0.987	Q8BJR6 →
Q9N2D1	—	0.985	Q9N2D1 →
Q9QYZ9	—	0.985	Q9QYZ9 →
KLK13	Kallikrein-13	0.985	landscape →
P09582	—	0.984	P09582 →
A6NIE9	—	0.984	A6NIE9 →
P32038	—	0.981	P32038 →
A1L453	—	0.981	A1L453 →
P35034	—	0.980	P35034 →
Q9JHJ7	—	0.980	Q9JHJ7 →
Q28773	—	0.979	Q28773 →
Q6BEA2	—	0.979	Q6BEA2 →
P51779	—	0.979	P51779 →
P03953	—	0.979	P03953 →
Q9ESD1	—	0.979	Q9ESD1 →
P33619	—	0.979	P33619 →
KLK1	Kallikrein-1	0.978	landscape →
KLK3	Prostate-specific antigen	0.978	landscape →
P83748	—	0.977	P83748 →
P15944	—	0.977	P15944 →
Q7Z5A4	—	0.976	Q7Z5A4 →
P36369	—	0.976	P36369 →