Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312311 | 0.80 | BRD4 (0.44) | ADRA1AGAAPARP1 | |
| SCHEMBL10468029 | 0.77 | PARP1 (0.42) | GAAPARP1 | |
| SCHEMBL10468977 | 0.71 | BRD4 (0.44) | GAAPARP1 | |
| SCHEMBL10836480 | 0.71 | TLR4 (0.38) | ADRA1A | |
| Hydrochloric Acid SCHEMBL10836770 | 0.71 | ADRA1A (0.51) | ADRA1A | |
| SCHEMBL10838426 | 0.70 | ADRA1A (0.42) | ADRA1ANQO2MTNR1AMTNR1B | |
| SCHEMBL15911203 | 0.69 | ADRA1A (0.49) | ADRA1AKDM4EALDH1A1GLAGAA | |
| Hydrochloric Acid SCHEMBL10838511 | 0.69 | ADRA1A (0.43) | ADRA1A | |
| Hydrochloric Acid SCHEMBL10838208 | 0.69 | ADRA1A (0.43) | ADRA1A | |
| Hydrochloric Acid SCHEMBL10836525 | 0.69 | ADRA1A (0.43) | ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4564698-A | Biologically-active tricyclic amines | AKZO N.V. (NL) | 1986-01-14 | — | — | US | disclosed |
| EP-0041293-B1 | BIOLOGICALLY-ACTIVE TRICYCLIC AMINES, METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AKZO N.V. (NL) | 1984-03-14 | — | — | EP | disclosed |
| WO-1981003490-A1 | BIOLOGICALLY-ACTIVE TRICYCLIC AMINES,METHODS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AKZO NV (NL) | 1981-12-10 | — | — | WO | disclosed |
| EP-0041293-A1 | Biologically-active tricyclic amines, methods for their preparation and pharmaceutical compositions containing same | AKZO N.V. (NL) | 1981-12-09 | — | — | EP | disclosed |