ADRA1A

Alpha-1A adrenergic receptor · P35348 · ADRA1A on Sugi Atlas →

607,857 patent compounds predicted against ADRA1A, 428,418 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Azelastine (SCHEMBL4239)	1.00	17/20
Azelastine (SCHEMBL4240)	1.00	17/20
Labetalol (SCHEMBL4582)	1.00	13/20
Phentolamine (SCHEMBL5653)	1.00	7/20
Promethazine (SCHEMBL4700)	1.00	6/20
Amitriptyline (SCHEMBL7824)	1.00	6/20
Cyproheptadine (SCHEMBL4021)	1.00	5/20
Chlorpromazine (SCHEMBL8321)	1.00	5/20
Ketotifen (SCHEMBL4436)	1.00	4/20
Clonidine (SCHEMBL5983)	1.00	4/20
Bisantrene (SCHEMBL7472)	1.00	4/20
Haloperidol (SCHEMBL8264)	1.00	4/20
Bisantrene (SCHEMBL4773)	0.97	4/20
Pipamperone (SCHEMBL7405)	0.94	4/20
Ketotifen (SCHEMBL8809)	0.83	4/20
Ketotifen (SCHEMBL8810)	0.83	4/20
SCHEMBL2250	0.61	4/20
Traxoprodil (SCHEMBL4248)	0.55	4/20
Ergotamine (SCHEMBL1483)	1.00	3/20
Pipamperone (SCHEMBL2412)	1.00	3/20

Clinical trials — most relevant to ADRA1A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences	PHASE4	RECRUITING
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Dexmedetomidine Adjuvant Treatment for Depressed Patients Undergoing ECT	PHASE4	UNKNOWN
Reversal of Acute β-Blocker Induced Bronchoconstriction	PHASE4	COMPLETED
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Lidocaine vs. Lidocaine With Dexmedetomidine for Intravenous Regional Anesthesia (IVRA) in Upper Limb Surgery	PHASE4	RECRUITING
Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome	PHASE3	RECRUITING
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure	PHASE3	COMPLETED
Best African American Response to Asthma Drugs	PHASE3	COMPLETED
Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)	PHASE2/PHASE3	COMPLETED
Analgesia After Laparoscopic Cholecystectomy	PHASE2	UNKNOWN
Prazosin for Alcohol Dependence and Posttraumatic Stress Disorder	PHASE2	COMPLETED
Mechanisms for Activation of Beige Adipose Tissue in Humans	PHASE2	RECRUITING
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children	PHASE1	COMPLETED
Dose Response and Receptor Selectivity of Beta-blocker Effects on Bone Metabolism	EARLY_PHASE1	COMPLETED
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Effects of Chronic Use of Doxazosin in Men With Benign Prostatic Hyperplasia	nan	COMPLETED
The Mechanism of Endogenous Nociceptin/Orphanin FQ(N/OFQ) and β1-adrenoceptor Autoantibody in Promoting Ischemic Arrhythmia in Rats	nan	NOT_YET_RECRUITING
The Impact of Early Norepinephrine Administration on Outcomes of Patients With Sepsis-induced Hypotension	nan	COMPLETED
Clinical Effect and Safety of Tamsulosin 0.4mg in Patients With LUTS/BPH Refractory to Tamsulosin 0.2mg	nan	UNKNOWN
Influence of Nebivolol on Postmenopausal Women	nan	UNKNOWN
Common Noradrenergic Mechanisms in Parkinson´s Disease and L-DOPA Induced Dyskinesia	nan	UNKNOWN
Acute Airway Vascular Smooth Muscle Effects of Inhaled Budesonide	nan	COMPLETED
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine	nan	WITHDRAWN
Add-on Salmeterol Versus Montelukast in Arg/Arg-16 Asthmatics	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADRA1A binder may also engage these)

Protein	Name	Similarity
P18130	—	1.000	P18130 →
Q9WU25	—	1.000	Q9WU25 →
P97718	—	1.000	P97718 →
O02824	—	1.000	O02824 →
P43140	—	1.000	P43140 →
Q91175	—	0.998	Q91175 →
Q28997	—	0.996	Q28997 →
P54833	—	0.992	P54833 →
P18901	—	0.992	P18901 →
Q5IS72	—	0.991	Q5IS72 →
P97292	—	0.991	P97292 →
Q4KWL2	—	0.991	Q4KWL2 →
P04274	—	0.990	P04274 →
P97717	—	0.990	P97717 →
P50130	—	0.990	P50130 →
P15823	—	0.989	P15823 →
P25115	—	0.989	P25115 →
Q95136	—	0.989	Q95136 →
P52703	—	0.989	P52703 →
P70174	—	0.989	P70174 →
Q75Z89	—	0.989	Q75Z89 →
P42288	—	0.989	P42288 →
P10608	—	0.988	P10608 →
DRD1	D(1A) dopamine receptor	0.988	landscape →
Q5R4Q6	—	0.988	Q5R4Q6 →
DRD3	D(3) dopamine receptor	0.988	landscape →
P53452	—	0.987	P53452 →
Q8N6U8	—	0.987	Q8N6U8 →
O42384	—	0.987	O42384 →
P19020	—	0.987	P19020 →