Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 0.90 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.90 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.62 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3517955 | 0.95 | SLC6A3 (1.00) | SLC6A4SLC6A3SLC6A2GRIN1GRIN2A | |
| SCHEMBL13755349 | 0.81 | SLC6A4 (0.72) | SLC6A4SLC6A3SLC6A2MAOBMAOA | |
| SCHEMBL15065608 | 0.79 | SLC6A4 (0.68) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL10623441 | 0.78 | SLC6A4 (0.89) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL12235288 | 0.77 | SLC6A3 (0.71) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL13755350 | 0.77 | SLC6A4 (0.61) | SLC6A4SLC6A3SLC6A2MAOBMAOA | |
| SCHEMBL20194921 | 0.76 | SLC6A4 (0.65) | SLC6A4SLC6A3SLC6A2CYP3A4GRIN1 | |
| Hydrochloric Acid SCHEMBL2163 | 0.76 | SLC6A3 (0.59) | SLC6A4SLC6A3SLC6A2TP53CYP3A4 | |
| SCHEMBL19388511 | 0.76 | SLC6A4 (0.64) | SLC6A4SLC6A3SLC6A2GRIN1GRIN2A | |
| SCHEMBL3520894 | 0.76 | SLC6A4 (1.00) | SLC6A4SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4629727-A | ANTIDEPRESSANTS | THE BOOTS COMPANY PLC (GB) | 1986-12-16 | — | — | US | disclosed |
| EP-0111994-B1 | (1-ARYLCYCLOBUTYL) ALKYLAMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1986-02-26 | — | — | EP | disclosed |
| EP-0111994-A1 | (1-Arylcyclobutyl) alkylamine derivatives, their preparation and their use as therapeutic agents | The Boots Company PLC (GB) | 1984-06-27 | — | — | EP | disclosed |