Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 4/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.56 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 10/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10342887 | 0.90 | LTB4R (0.66) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 | |
| SCHEMBL10836882 | 0.84 | LTB4R (0.57) | LTB4RLTB4R2TDP1 | |
| SCHEMBL10342894 | 0.83 | LTB4R (0.56) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 | |
| SCHEMBL10638732 | 0.82 | LTB4R (0.51) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 | |
| SCHEMBL10811298 | 0.82 | CYSLTR1 (0.50) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 | |
| SCHEMBL10805657 | 0.81 | LTB4R (0.58) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 | |
| SCHEMBL10344388 | 0.81 | CYSLTR1 (0.61) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 | |
| SCHEMBL10737074 | 0.81 | CYSLTR1 (0.60) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 | |
| SCHEMBL10731283 | 0.80 | CYSLTR2 (0.59) | LTB4RLTB4R2CYSLTR1CYSLTR2GRM2 | |
| SCHEMBL10344115 | 0.79 | PPARG (0.56) | LTB4RLTB4R2CYSLTR1CYSLTR2TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150447-A2 | Substituted dihydrobenzopyran-2-carboxylates | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | claimed |
| US-4565882-A | Substituted dihydrobenzopyran-2-carboxylates | G. D. SEARLE & CO. (US) | 1986-01-21 | — | — | US | disclosed |
| EP-0150447-A2 | Substituted dihydrobenzopyran-2-carboxylates | G.D. Searle & Co. (US) | 1985-08-07 | — | — | EP | disclosed |