Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 10/20 | 0.66 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.66 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | CASR | P41180 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18506359 | 0.92 | ADRB3 (0.60) | ADRB3ADRB2ADRB1KMT2AMAPT | |
| SCHEMBL20436123 | 0.88 | ADRB3 (0.54) | ADRB3ADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL13719534 | 0.87 | ADRB3 (0.68) | ADRB3ADRB2ADRB1ALDH1A1KMT2A | |
| SCHEMBL17038022 | 0.86 | ADRB3 (0.71) | ADRB3ADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL17038023 | 0.86 | ADRB3 (0.71) | ADRB3ADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL10836940 | 0.85 | ATM (0.53) | ADRB3ADRB2ADRB1ALDH1A1KMT2A | |
| SCHEMBL11376334 | 0.85 | KMT2A (0.56) | ADRB3ADRB2ADRB1KMT2AMAPT | |
| SCHEMBL18506367 | 0.85 | ADRB3 (0.61) | ADRB3ADRB2ADRB1KMT2AMEN1 | |
| SCHEMBL7327969 | 0.84 | MEN1 (0.68) | ADRB3ADRB2ADRB1KMT2AMAPT | |
| SCHEMBL20441143 | 0.84 | KDM4E (0.60) | ADRB3ADRB2ADRB1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4608383-A | Cardioactive pyrazole and imidazole aryloxypropanolamines | BOEHRINGER MANNHEIM GMBH (DE) | 1986-08-26 | — | — | US | disclosed |
| EP-0042593-B1 | ARYLOXY-PROPANOL AMINES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1985-04-03 | — | — | EP | disclosed |
| US-4438128-A | ADRENERGIC BLOCKERS | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |
| EP-0042593-A1 | Aryloxy-propanol amines, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |