Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 7/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11009261 | 0.93 | PLA2G4B (0.54) | ATMADRB3ADRB2ADRB1CYP1A2 | |
| SCHEMBL11488238 | 0.92 | ADRB3 (0.51) | ATMADRB3ADRB2ADRB1CYP1A2 | |
| SCHEMBL20436123 | 0.91 | ADRB3 (0.54) | ATMADRB3ADRB2ADRB1CYP1A2 | |
| SCHEMBL18506359 | 0.89 | ADRB3 (0.60) | ATMADRB3ADRB2ADRB1CYP1A2 | |
| SCHEMBL11499941 | 0.87 | ADRB3 (0.53) | ATMADRB3ADRB2ADRB1CYP1A2 | |
| SCHEMBL11488244 | 0.86 | ADRB3 (0.44) | ATMADRB3ADRB2ADRB1CYP1A2 | |
| SCHEMBL10838546 | 0.85 | ADRB3 (0.66) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL20436115 | 0.85 | ADRB3 (0.54) | ADRB3ADRB2ADRB1MEN1KMT2A | |
| SCHEMBL17038023 | 0.84 | ADRB3 (0.71) | ADRB3ADRB2ADRB1MEN1OPRM1 | |
| SCHEMBL17038022 | 0.84 | ADRB3 (0.71) | ADRB3ADRB2ADRB1MEN1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4608383-A | Cardioactive pyrazole and imidazole aryloxypropanolamines | BOEHRINGER MANNHEIM GMBH (DE) | 1986-08-26 | — | — | US | disclosed |
| US-4438128-A | ADRENERGIC BLOCKERS | BOEHRINGER MANNHEIM GMBH (DE) | 1984-03-20 | — | — | US | disclosed |
| EP-0042593-A1 | Aryloxy-propanol amines, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1981-12-30 | — | — | EP | disclosed |