Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 7/20 | 0.73 |
| ▸ | THRA | P10827 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10840947 | 1.00 | SMPD1 (0.73) | SMPD1THRATP53TSHR | |
| SCHEMBL10840940 | 1.00 | SMPD1 (0.73) | SMPD1THRATP53TSHR | |
| SCHEMBL10839296 | 1.00 | SMPD1 (0.73) | SMPD1THRATP53TSHR | |
| SCHEMBL10840061 | 0.96 | SMPD1 (0.66) | SMPD1THRA | |
| SCHEMBL8400936 | 0.86 | THRA (0.59) | SMPD1THRATP53TSHR | |
| SCHEMBL7271669 | 0.85 | TP53 (0.77) | THRATP53TSHR | |
| SCHEMBL14672324 | 0.85 | TP53 (0.77) | THRATP53TSHR | |
| SCHEMBL5388136 | 0.85 | TP53 (0.77) | THRATP53TSHR | |
| SCHEMBL5383674 | 0.85 | TP53 (0.77) | THRATP53TSHR | |
| SCHEMBL9779326 | 0.85 | TP53 (0.77) | THRATP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199152-A2 | Lipoxygenase inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4605669-A | Lipoxygenase inhibiting naphthohydroxamic acids | ABBOTT LABORATORIES (US) | 1986-08-12 | — | — | US | disclosed |