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THRA

Thyroid hormone receptor alpha · P10827 · THRA on Sugi Atlas →

121,480 patent compounds predicted against THRA, 64,639 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL187096 SCHEMBL187096 0.63 11/20
Liothyronine Liothyronine (SCHEMBL8300) 1.00 10/20
Detrothyronine Detrothyronine (SCHEMBL8301) 1.00 10/20
Rathyronine Rathyronine (SCHEMBL123365) 1.00 10/20
Axitirome Axitirome (SCHEMBL126256) 1.00 10/20
SCHEMBL83484 SCHEMBL83484 0.68 10/20
SCHEMBL75643 SCHEMBL75643 0.65 10/20
SCHEMBL195471 SCHEMBL195471 0.61 10/20
SCHEMBL151548 SCHEMBL151548 0.59 10/20
SCHEMBL195074 SCHEMBL195074 0.59 10/20
Tiratricol Tiratricol (SCHEMBL25149) 1.00 9/20
Detrothyronine Detrothyronine (SCHEMBL41654) 0.78 9/20
Detrothyronine Detrothyronine (SCHEMBL41655) 0.76 9/20
SCHEMBL158152 SCHEMBL158152 0.67 9/20
SCHEMBL75644 SCHEMBL75644 0.65 9/20
SCHEMBL51732 SCHEMBL51732 0.61 9/20
SCHEMBL101905 SCHEMBL101905 0.58 9/20
SCHEMBL81096 SCHEMBL81096 0.56 9/20
SCHEMBL74264 SCHEMBL74264 0.56 8/20
SCHEMBL195630 SCHEMBL195630 0.56 8/20

Clinical trials — most relevant to THRA by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused by Thyroidectomy in Thyroid Cancer Patients. PHASE4UNKNOWN
Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules in Type 2 Diabetes PHASE4UNKNOWN
Neurocognitive and Metabolic Effects of Mild Hypothyroidism PHASE4COMPLETED
A Study to Learn if Recombinant Human Parathyroid Hormone [rhPTH(1-84)] Can Improve Symptoms and Metabolic Control in Adults With Hypoparathyroidism (BALANCE) PHASE4COMPLETED
Glycerol-Phenylbutyrate Treatment in Children With MCT Mutation (Allan-Herndon- Dudley Syndrome) PHASE2/PHASE3UNKNOWN
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study) PHASE3RECRUITING
Impact of PCSK9 Inhibitors on Coronary Microvascular Dysfunction in Patients With Atherosclerotic Cardiovascular Disease Proved by Myocardial Ischemia and Needing Coronarography PHASE2UNKNOWN
Intrathecal Gene Therapy For SLC13A5 Citrate Transporter Disorder PHASE1/PHASE2NOT_YET_RECRUITING
Denosumab vs Placebo in Patients With Thalassemia Major and Osteoporosis PHASE2COMPLETED
Thyroid and Glucose and Energy Metabolism PHASE2COMPLETED
Study of Thyrotropin-Releasing Hormone in Normal Volunteers and in Patients With Thyroid or Pituitary Abnormalities PHASE2COMPLETED
Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo PHASE2COMPLETED
Pegylated Interferon Alfa-2a Maintenance Therapy and Liver Disease Progression in People Infected With Both HIV and Hepatitis C Virus (HCV) PHASE2COMPLETED
Investigating the Effect of Obicetrapib on Lipoprotein Metabolism PHASE1ACTIVE_NOT_RECRUITING
Understanding, Diagnosis and Monitoring of Thyroid Hormone Action Defects nanRECRUITING
Register for Patients With Thyroid Hormone Resistance. nanRECRUITING
Thyroid Function in Liver Cirrhosis: Is it Affected? nanCOMPLETED
Natural History of Thyroid Function Disorders nanRECRUITING
Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment nanCOMPLETED
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3 nanCOMPLETED
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism nanUNKNOWN
TSH Receptor Mutations Among a Consanguineous Community nanCOMPLETED
Effects of Thyroid Hormone Enzyme Blocking on Hypothyroidism nanWITHDRAWN
Improvement of Laboratory Diagnostics in Hypothyroid Patients Using Levothyroxine nanRECRUITING
Impact of Thyroid Hormones on Human Glucose and Energy Metabolism nanRECRUITING
NOMOTHETICOS: Nonlinear Modelling of Thyroid Hormones' Effect on Thyrotropin Incretion in Confirmed Open-loop Situation nanUNKNOWN
Short Term Outcome of Metabolic Associated Fatty Liver Disease (MAFLD) in Patients Undergoing Bariatric Surgery nanUNKNOWN
Polymorphisms in the Vitamin D System and Health nanCOMPLETED
Aromatase Inhibitor Clinical Trial nanUNKNOWN
Metabolism and Thyroid Hormone Changes During Exposure to Cold Temperatures nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a THRA binder may also engage these)

ProteinNameSimilarity
P63059 — 1.000 P63059 →
P63058 — 1.000 P63058 →
O97716 — 1.000 O97716 →
P03373 — 0.996 P03373 →
P37242 — 0.994 P37242 →
Q5RAP4 — 0.994 Q5RAP4 →
Q62685 — 0.993 Q62685 →
P18119 — 0.993 P18119 →
A3RGC1 — 0.993 A3RGC1 →
P18113 — 0.993 P18113 →
Q9XSB5 — 0.993 Q9XSB5 →
RORC Nuclear receptor ROR-gamma 0.993 landscape →
O54915 — 0.993 O54915 →
F1QLY4 — 0.992 F1QLY4 →
P51448 — 0.992 P51448 →
Q5E9B6 — 0.992 Q5E9B6 →
Q9R1A7 — 0.992 Q9R1A7 →
THRB Thyroid hormone receptor beta 0.992 landscape →
NR1H3 Oxysterols receptor LXR-alpha 0.992 landscape →
Q9XSW2 — 0.992 Q9XSW2 →
NR1I2 Nuclear receptor subfamily 1 group I member 2 0.991 landscape →
NR1H4 Bile acid receptor 0.991 landscape →
Q9TU15 — 0.991 Q9TU15 →
NR1H2 Oxysterols receptor LXR-beta 0.991 landscape →
Q3SZL0 — 0.991 Q3SZL0 →
Q0ZAQ8 — 0.991 Q0ZAQ8 →
P49701 — 0.991 P49701 →
VDR Vitamin D3 receptor 0.991 landscape →
Q28037 — 0.991 Q28037 →
Q9W785 — 0.991 Q9W785 →