Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 6/20 | 0.49 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.48 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
| ▸ | GBA1 | P04062 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084353 | 0.89 | MAPT (0.57) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084809 | 0.86 | ALDH1A1 (0.80) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084292 | 0.86 | MAPT (0.69) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084610 | 0.84 | ALDH1A1 (0.64) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084342 | 0.83 | ALDH1A1 (0.74) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084116 | 0.83 | ALDH1A1 (0.57) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL14406060 | 0.82 | ALDH1A1 (0.61) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084167 | 0.82 | ALDH1A1 (0.61) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084422 | 0.82 | MEN1 (0.74) | MAPTALDH1A1TSHRL3MBTL1MEN1 | |
| SCHEMBL1084449 | 0.81 | ALDH1A1 (0.67) | MAPTALDH1A1TSHRL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |