Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 1.00 |
| ▸ | MEN1 | O00255 | 9/20 | 1.00 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.80 |
| ▸ | PKM | P14618 | 2/20 | 0.80 |
| ▸ | EGFR | P00533 | 1/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.70 |
| ▸ | PDE5A | O76074 | 5/20 | 0.68 |
| ▸ | GBA1 | P04062 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | USP1 | O94782 | 2/20 | 0.67 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29754288 | 0.89 | MAPT (1.00) | KMT2AMEN1RXFP1MAPTNPSR1 | |
| SCHEMBL1083926 | 0.89 | MAPT (1.00) | KMT2AMEN1RXFP1MAPTNPSR1 | |
| SCHEMBL28611828 | 0.85 | MEN1 (0.73) | KMT2AMEN1RXFP1MAPTNPSR1 | |
| SCHEMBL1083874 | 0.83 | MAPK1 (1.00) | KMT2AMEN1RXFP1MAPTMAPK1 | |
| SCHEMBL28805460 | 0.83 | CYP1A2 (0.80) | KMT2AMEN1RXFP1MAPTMAPK1 | |
| SCHEMBL1083858 | 0.83 | MEN1 (0.71) | KMT2AMEN1RXFP1MAPTNPSR1 | |
| SCHEMBL1083949 | 0.83 | KMT2A (0.71) | KMT2AMEN1RXFP1MAPTNPSR1 | |
| SCHEMBL1083779 | 0.83 | CYP1A2 (0.80) | KMT2AMEN1RXFP1MAPTMAPK1 | |
| SCHEMBL1083885 | 0.82 | KMT2A (1.00) | KMT2AMEN1RXFP1MAPTNPSR1 | |
| SCHEMBL3917004 | 0.82 | MEN1 (0.70) | KMT2AMEN1RXFP1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |