Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 2/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.62 |
| ▸ | PDE10A | Q9Y233 | 11/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | MAT2A | P31153 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084394 | 0.89 | HRH4 (0.49) | HTR3AHRH4PDE10AMAT2APRMT5 | |
| SCHEMBL1084180 | 0.83 | HTR3A (0.43) | HTR3AHRH4EGLN1 | |
| SCHEMBL1084347 | 0.82 | HTR3A (0.65) | HTR3AHRH4PDE10ACSF1RMAT2A | |
| SCHEMBL938725 | 0.81 | CSF1R (0.46) | HTR3AHRH4CSF1RPDE5AEGLN1 | |
| SCHEMBL1083951 | 0.80 | SMN1; SMN2 (0.53) | PDE5AEGLN1 | |
| SCHEMBL15538645 | 0.77 | HTR3A (0.57) | HTR3AHRH4PDE10ACSF1RMAT2A | |
| SCHEMBL715586 | 0.74 | PDE5A (0.57) | HTR3AHRH4CSF1RPDE5A | |
| SCHEMBL1083797 | 0.69 | CYP1A2 (0.51) | HTR3AHRH4PDE10ACSF1RMAT2A | |
| SCHEMBL1084188 | 0.69 | CYP1A2 (0.50) | HTR3AHRH4PDE10ACSF1R | |
| SCHEMBL937891 | 0.68 | HTR3A (0.43) | HTR3AHRH4CSF1RPDE5AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |