HTR3A

5-hydroxytryptamine receptor 3A · P46098 · HTR3A on Sugi Atlas →

182,397 patent compounds predicted against HTR3A, 113,550 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Granisetron (SCHEMBL4890)	1.00	12/20
Granisetron (SCHEMBL4891)	1.00	12/20
Granisetron (SCHEMBL34178)	1.00	12/20
Granisetron (SCHEMBL33433)	0.98	12/20
Granisetron (SCHEMBL34177)	0.98	12/20
Granisetron (SCHEMBL34179)	0.98	12/20
SCHEMBL76793	0.53	11/20
Palonosetron (SCHEMBL3746)	1.00	10/20
Palonosetron (SCHEMBL3747)	1.00	10/20
Palonosetron (SCHEMBL3748)	1.00	10/20
Tropisetron (SCHEMBL18297)	1.00	9/20
Tropisetron (SCHEMBL18299)	1.00	9/20
Dolasetron (SCHEMBL42063)	1.00	8/20
Dolasetron (SCHEMBL42064)	1.00	8/20
Dolasetron (SCHEMBL42065)	1.00	8/20
Dolasetron (SCHEMBL41145)	0.88	8/20
Dolasetron (SCHEMBL41146)	0.88	8/20
SCHEMBL8689	0.55	8/20
Renzapride (SCHEMBL17037)	1.00	7/20
SCHEMBL4896	0.67	6/20

Clinical trials — most relevant to HTR3A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder	PHASE4	COMPLETED
Cariprazine Versus Placebo for Social Anxiety Disorder	PHASE4	COMPLETED
Vortioxetine for Depressive Symptoms and Freezing of Gait in Parkinson Disease	PHASE4	NOT_YET_RECRUITING
Clinical Neurobiology of Serotonin and Addiction	PHASE2/PHASE3	COMPLETED
Study to Evaluate AD04 in Adults With Alcohol Use Disorder (AUD) and Selected Serotonin Transporter Polymorphisms	PHASE3	COMPLETED
Vortioxetine for the Treatment of Hoarding Disorder	PHASE3	WITHDRAWN
5HT2CR Balance in Brain Connectivity in Cocaine Dependence	PHASE1/PHASE2	COMPLETED
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET	PHASE1/PHASE2	COMPLETED
Safety and Efficacy of MEM 3454 Versus Placebo in Patients With Mild to Moderate Alzheimer's Disease	PHASE2	COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder	PHASE2	RECRUITING
PET Imaging of Brain 5-HT(1A) Receptors Using [(11)C](-)-RWAY	PHASE1	COMPLETED
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
SRC Inhibition as a Potential Target for Parkinson's Disease Psychosis	EARLY_PHASE1	UNKNOWN
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
Investigating the Neuropsychological Effects of 5-HT2a Antagonism	nan	RECRUITING
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma	nan	ACTIVE_NOT_RECRUITING
Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain	nan	ENROLLING_BY_INVITATION
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
TSK (Tryptophan - Serotonin - Kynurenine) Biomarkers Assessment in Stroke	nan	COMPLETED
PET Whole Body Distribution Studies Using [11C]CUMI	nan	COMPLETED
Trazodone and the Risk of Serious Adverse Events	nan	COMPLETED
Intern Health Study	nan	ENROLLING_BY_INVITATION
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HTR3A binder may also engage these)

Protein	Name	Similarity
P23979	—	1.000	P23979 →
P35563	—	1.000	P35563 →
O70212	—	0.992	O70212 →
HTR3C	5-hydroxytryptamine receptor 3C (5-HT3-C) (5-	0.983	landscape →
HTR3E	5-hydroxytryptamine receptor 3E (5-HT3-E) (5-	0.960	landscape →
P09660	—	0.947	P09660 →
P20782	—	0.946	P20782 →
CHRNE	Acetylcholine receptor subunit epsilon	0.946	landscape →
P02715	—	0.946	P02715 →
P25109	—	0.944	P25109 →
HTR3B	5-hydroxytryptamine receptor 3B	0.943	landscape →
P56475	—	0.942	P56475 →
P02713	—	0.942	P02713 →
P04758	—	0.940	P04758 →
P56476	—	0.939	P56476 →
SCNN1A	Epithelial sodium channel subunit alpha	0.938	landscape →
O97741	—	0.937	O97741 →
P13536	—	0.936	P13536 →
P47742	—	0.936	P47742 →
GABRR1	Gamma-aminobutyric acid receptor subunit rho-1	0.936	landscape →
P04760	—	0.936	P04760 →
P34904	—	0.936	P34904 →
P09690	—	0.935	P09690 →
CHRNB1	Acetylcholine receptor subunit beta	0.935	landscape →
A2AIR5	—	0.935	A2AIR5 →
P50572	—	0.935	P50572 →
H2Q5A1	—	0.933	H2Q5A1 →
P55270	—	0.932	P55270 →
Q9P0L9	—	0.931	Q9P0L9 →
Q0II76	—	0.930	Q0II76 →