Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 6/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | GBA1 | P04062 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.59 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.59 |
| ▸ | USP1 | O94782 | 1/20 | 0.57 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083874 | 0.84 | MAPK1 (1.00) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL1083916 | 0.84 | CYP1A2 (0.70) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL1083811 | 0.83 | CYP1A2 (0.59) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL1084184 | 0.81 | CYP1A1 (0.77) | MAPTPOLBMAPK1LMNAMEN1 | |
| SCHEMBL1083808 | 0.81 | SMN1; SMN2 (1.00) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL1083895 | 0.80 | MEN1 (0.78) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL2590654 | 0.79 | MAPK1 (0.71) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL1084254 | 0.78 | KMT2A (1.00) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL1084100 | 0.77 | GBA1 (0.64) | MAPTPOLBMAPK1LMNASMN1; SMN2 | |
| SCHEMBL2587526 | 0.77 | KMT2A (1.00) | MAPTPOLBMAPK1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |