Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | GBA1 | P04062 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.59 |
| ▸ | CDK2 | P24941 | 4/20 | 0.59 |
| ▸ | CDK4 | P11802 | 2/20 | 0.59 |
| ▸ | CCND1 | P24385 | 2/20 | 0.59 |
| ▸ | CLK1 | P49759 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.53 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.53 |
| ▸ | LATS1 | O95835 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1083895 | 0.88 | MEN1 (0.78) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL5103688 | 0.82 | KMT2A (1.00) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL1083916 | 0.80 | CYP1A2 (0.70) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL2588898 | 0.77 | MEN1 (0.84) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL1084178 | 0.77 | MAPT (0.73) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL16183673 | 0.75 | MEN1 (0.67) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL25243367 | 0.75 | MAPT (0.67) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL7278023 | 0.74 | MEN1 (0.87) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL1084783 | 0.73 | MAPT (0.78) | KMT2AMEN1GBA1MAPTHTT | |
| SCHEMBL1083874 | 0.73 | MAPK1 (1.00) | KMT2AMEN1GBA1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103068393-A | Methods and compositions for inhibition of the transitional endoplasmic reticulum atpase | CLEAVE BIOSCIENCES INC CLEAVE | 2013-04-24 | — | — | CN | disclosed |
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |