Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 13/20 | 0.72 |
| ▸ | MEN1 | O00255 | 12/20 | 0.72 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2291715 | 0.85 | MEN1 (0.67) | KMT2AMEN1MAPTRXFP1LMNA | |
| SCHEMBL5107131 | 0.84 | MEN1 (0.73) | KMT2AMEN1MAPTRXFP1LMNA | |
| SCHEMBL1083802 | 0.83 | MEN1 (0.81) | KMT2AMEN1MAPTNPSR1RXFP1 | |
| SCHEMBL1084165 | 0.76 | CYP1A2 (0.70) | KMT2AMEN1MAPTNPSR1RXFP1 | |
| SCHEMBL1084199 | 0.76 | KMT2A (0.57) | KMT2AMEN1MAPTNPSR1RXFP1 | |
| SCHEMBL802012 | 0.75 | AURKA (0.72) | KMT2AMEN1ALKPOLBNTRK1 | |
| SCHEMBL785448 | 0.75 | MEN1 (0.60) | KMT2AMEN1MAPTNPSR1RXFP1 | |
| SCHEMBL2233756 | 0.75 | MAPT (0.62) | KMT2AMEN1MAPTLMNAL3MBTL1 | |
| SCHEMBL22201482 | 0.74 | ABCG2 (0.64) | KMT2AMEN1MAPTL3MBTL1POLB | |
| SCHEMBL801777 | 0.74 | GSK3A (0.72) | KMT2AMEN1MAPTNPSR1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |