SCHEMBL10846005

SCHEMBL10846005

c1cc(CCC2=NCCCCN2)ccn1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.57
MAOB P27338 1/20 0.57
NISCH Q9Y2I1 1/20 0.57
HTR1D P28221 2/20 0.41
TAAR1 Q96RJ0 2/20 0.41
HRH3 Q9Y5N1 2/20 0.40
TDP1 Q9NUW8 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
CYP1A2 P05177 2/20 0.39
LMNA P02545 1/20 0.39
ADRA2A P08913 1/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.39
ADRA2B P18089 1/20 0.39
ADRA2C P18825 1/20 0.39
ADRA1D P25100 1/20 0.39
ADRA1A P35348 1/20 0.39
ADRA1B P35368 1/20 0.39
HRH4 Q9H3N8 1/20 0.39
CYP3A4 P08684 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11884449 0.81 NISCH (0.80) MAOAMAOBNISCHTAAR1CYP1A2
SCHEMBL7005260 0.79 TAAR1 (0.58) HTR1DTAAR1CYP1A2LMNAADRA2A
SCHEMBL4041332 0.78 MAOB (0.56) MAOAMAOBNISCHHTR1DTAAR1
SCHEMBL4035129 0.78 NISCH (0.56) MAOAMAOBNISCHHTR1DTAAR1
Phenyzoline SCHEMBL3172677 0.73 NISCH (1.00) MAOAMAOBNISCHHTR1DTAAR1
SCHEMBL4032771 0.72 MAOB (0.49) MAOAMAOBNISCHHTR1DTAAR1
SCHEMBL10846015 0.71 TAAR1 (0.72) MAOAMAOBNISCHHTR1DTAAR1
SCHEMBL4033870 0.70 NISCH (0.69) MAOAMAOBNISCHHTR1DTAAR1
SCHEMBL3178397 0.70 MAOA (0.69) MAOAMAOBNISCHHTR1DTAAR1
Hydrochloric Acid SCHEMBL4711895 0.70 MAOA (0.69) MAOAMAOBNISCHHTR1DTAAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4605744-A ANTIBIOTICS HOFFMANN-LA ROCHE INC. (US) 1986-08-12 US disclosed
US-4537969-A AZOLE-SUBSTITUTED SATURATED HETEROCYCLIC CARBOXALDEHYDE ACETALS;INTERMEDIATES FOR 6-AMIDINOPENICILLINS HOFFMANN-LA ROCHE INC. (US) 1985-08-27 US disclosed
EP-0148283-A1 Novel penicillanic acid derivatives F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1985-07-17 EP disclosed
US-4431653-A ANTIBIOTICS; BACTERICIDES; SSYNERGISTIC WITH AMINO ACID DERIVATIVE HOFFMANN-LA ROCHE INC. (US) 1984-02-14 US disclosed