Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | FKBP1A | P62942 | 8/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084067 | 0.88 | SMAD3 (0.43) | SMAD3MAPTL3MBTL1KMT2AMEN1 | |
| SCHEMBL14406472 | 0.83 | SMAD3 (0.43) | SMAD3MAPTL3MBTL1ALDH1A1TSHR | |
| SCHEMBL1084873 | 0.83 | CHEK2 (0.46) | SMAD3MAPTL3MBTL1ALDH1A1TSHR | |
| SCHEMBL1084083 | 0.82 | GBA1 (0.50) | SMAD3MAPTL3MBTL1ALDH1A1TSHR | |
| SCHEMBL12722524 | 0.80 | SMAD3 (0.45) | GFERSMAD3MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL1084478 | 0.79 | ALDH1A1 (0.53) | SMAD3MAPTL3MBTL1ALDH1A1TSHR | |
| SCHEMBL1623244 | 0.79 | SMAD3 (0.41) | SMAD3MAPTL3MBTL1ALDH1A1TSHR | |
| SCHEMBL1623453 | 0.79 | MAPT (0.40) | GFERSMAD3MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL12722578 | 0.79 | SMAD3 (0.46) | GFERSMAD3MAPTL3MBTL1ALDH1A1 | |
| SCHEMBL12722615 | 0.79 | SMAD3 (0.46) | GFERSMAD3MAPTL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8343980-B2 | Quinazoles useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-01-01 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-8153642-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-10 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7713983-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-05-11 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |