Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | PRCP | P42785 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 4/20 | 0.38 |
| ▸ | HTR2B | P41595 | 4/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31350550 | 0.86 | SMN1; SMN2 (0.76) | SMN1; SMN2KMT2AGAAPRCPMEN1 | |
| SCHEMBL11439131 | 0.86 | SMN1; SMN2 (0.76) | SMN1; SMN2KMT2AGAAPRCPMEN1 | |
| SCHEMBL21035183 | 0.86 | SMN1; SMN2 (0.76) | SMN1; SMN2KMT2AGAAPRCPMEN1 | |
| SCHEMBL21035184 | 0.86 | SMN1; SMN2 (0.76) | SMN1; SMN2KMT2AGAAPRCPMEN1 | |
| SCHEMBL10851883 | 0.84 | SMN1; SMN2 (1.00) | SMN1; SMN2KMT2AGAAPRCPSLC6A2 | |
| SCHEMBL4996430 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2KMT2AGAAPRCPANPEP | |
| SCHEMBL7427398 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2KMT2AGAAPRCPANPEP | |
| SCHEMBL10857077 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2KMT2AGAAPRCPSLC6A2 | |
| SCHEMBL10856095 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2AGAASLC6A3ALDH1A1 | |
| SCHEMBL10855259 | 0.80 | SMN1; SMN2 (0.67) | SMN1; SMN2KMT2AGAAPRCPALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4578393-A | ANTI-INFLAMMATORY AND ANT--PHEUMATIC | BEECHAM GROUP P.L.C. (GB) | 1986-03-25 | — | — | US | disclosed |
| EP-0139296-A2 | Dihydroisoquinoline derivatives | BEECHAM GROUP PLC (GB) | 1985-05-02 | — | — | EP | disclosed |