Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 2/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | TRPM5 | Q9NZQ8 | 4/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | TRPM4 | Q8TD43 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10857007 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2AGAAAHRCMA1 | |
| SCHEMBL10850802 | 0.84 | SMN1; SMN2 (0.72) | SMN1; SMN2KMT2AGAACRHBPCRHR2 | |
| SCHEMBL10854785 | 0.80 | CRHBP (0.67) | SMN1; SMN2KMT2ACRHBPCRHR2TP53 | |
| SCHEMBL10859456 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2AGAAAHRCMA1 | |
| SCHEMBL10853257 | 0.76 | CRHBP (0.49) | SMN1; SMN2KMT2AGAACRHBPCRHR2 | |
| SCHEMBL2387976 | 0.76 | CRHBP (0.55) | SMN1; SMN2KMT2ACRHBPCRHR2KDM1A | |
| SCHEMBL2393687 | 0.76 | CRHBP (0.55) | SMN1; SMN2KMT2ACRHBPCRHR2KDM1A | |
| SCHEMBL10856095 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2KMT2AGAACRHBPCRHR2 | |
| SCHEMBL23842064 | 0.73 | CRHBP (0.58) | KMT2ACRHBPCRHR2MDM2 | |
| SCHEMBL14375817 | 0.73 | CRHBP (0.44) | KMT2ACRHBPCRHR2KDM1AMDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0139296-A2 | Dihydroisoquinoline derivatives | BEECHAM GROUP PLC (GB) | 1985-05-02 | — | — | EP | claimed |
| US-4578393-A | ANTI-INFLAMMATORY AND ANT--PHEUMATIC | BEECHAM GROUP P.L.C. (GB) | 1986-03-25 | — | — | US | disclosed |
| EP-0139296-A2 | Dihydroisoquinoline derivatives | BEECHAM GROUP PLC (GB) | 1985-05-02 | — | — | EP | disclosed |