Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 3/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11112201 | 0.97 | HTR5A (0.39) | HTR5ACHRM2HTR1ACHRM5ADRA2A | |
| SCHEMBL11113912 | 0.90 | EGFR (0.41) | HTR5ASLC6A2HRH1ABCB1ABCG2 | |
| SCHEMBL10808165 | 0.89 | TP53 (0.39) | HTR5AABCB1ABCG2KDM4ESLC6A4 | |
| SCHEMBL10854756 | 0.89 | ABCB1 (0.40) | ABCB1ABCG2KDM4ESLC6A4MEN1 | |
| SCHEMBL10859924 | 0.89 | ABCB1 (0.38) | HTR5AABCB1ABCG2CYP1A2KDM4E | |
| SCHEMBL10804503 | 0.89 | ABCB1 (0.40) | HTR5AABCB1ABCG2KDM4ESLC6A4 | |
| SCHEMBL10804195 | 0.89 | ABCB1 (0.38) | HTR5AABCB1ABCG2CYP1A2KDM4E | |
| Hydrochloric Acid SCHEMBL10851788 | 0.88 | ABCB1 (0.37) | HTR5AABCB1ABCG2CYP1A2KDM4E | |
| SCHEMBL10851703 | 0.87 | ABCB1 (0.41) | HTR5AABCB1ABCG2CYP1A2KDM4E | |
| SCHEMBL11105995 | 0.86 | TP53 (0.39) | HTR5AABCB1ABCG2KDM4ESLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4575508-A | 2-Substituted 1-(3'-aminoalkyl)-1,2,3,4-tetrahydro-β-carbolines, and their use as antiarrhythmic agents | BASF AKTIENGESELLSCHAFT (DE) | 1986-03-11 | — | — | US | disclosed |
| EP-0101574-A1 | 2-Substituted 1-aminoalkyl-1,2,3,4-tetrahydro-beta-carbolines, their preparation and use as medicaments | BASF Aktiengesellschaft (DE) | 1984-02-29 | — | — | EP | disclosed |