HTR5A

5-hydroxytryptamine receptor 5A · P47898 · HTR5A on Sugi Atlas →

72,500 patent compounds predicted against HTR5A, 49,638 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Almotriptan (SCHEMBL1957)	0.65	11/20
SCHEMBL1437	0.64	11/20
Almotriptan (SCHEMBL2166)	0.64	11/20
Hydrochloric Acid (SCHEMBL2312)	0.63	11/20
SCHEMBL111992	0.58	10/20
SCHEMBL1453	0.55	9/20
Quazinone (SCHEMBL120977)	0.38	6/20
SCHEMBL44824	0.53	5/20
SCHEMBL88280	0.43	5/20
SCHEMBL88685	0.41	5/20
SCHEMBL134599	0.39	5/20
SCHEMBL61132	0.37	5/20
Seperidol (SCHEMBL124937)	0.71	4/20
Seperidol (SCHEMBL124936)	0.70	4/20
SCHEMBL178071	0.64	4/20
Zolmitriptan (SCHEMBL33336)	0.54	4/20
Zolmitriptan (SCHEMBL40595)	0.54	4/20
Penfluridol (SCHEMBL93939)	1.00	3/20
Promazine (SCHEMBL140489)	1.00	3/20
Promazine (SCHEMBL123418)	0.97	3/20

Clinical trials — most relevant to HTR5A by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Serotonin Transporter Genetic Variation and Amygdala Responses to Antidepressant Medications in Major Depression	PHASE4	COMPLETED
The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive Disorder	PHASE4	COMPLETED
Serotonergic Modulation of Cognition, Emotion and Brain Activation in Healthy Volunteers	PHASE4	COMPLETED
Clinical Neurobiology of Serotonin and Addiction	PHASE2/PHASE3	COMPLETED
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression	PHASE1/PHASE2	RECRUITING
5HT2CR Balance in Brain Connectivity in Cocaine Dependence	PHASE1/PHASE2	COMPLETED
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder	PHASE2	RECRUITING
The Effect of Ginger on the Incidence of Postoperative Nausea and Vomiting	PHASE2	COMPLETED
The Neurobiological Effect of 5-HT2AR Modulation	PHASE1	RECRUITING
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects	PHASE1	COMPLETED
Study Evaluating Safety, Tolerability, Pharmacokinetics and 5 HT1A Receptor Occupancy	PHASE1	COMPLETED
Evaluation of [18F]MPPF as a Brain Tracer of Serotonin Receptor 5HT1a	PHASE1	COMPLETED
Epigenetic and Neurochemical Correlates of Bipolar Disorder	nan	NOT_YET_RECRUITING
Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors	nan	COMPLETED
Examination of Brain Serotonin Receptors in Patients With Mood Disorders	nan	COMPLETED
The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers	nan	COMPLETED
Using Fenfluramine to Test the Serotonin Deficiency Theory of Depression	nan	NOT_YET_RECRUITING
The Pill Project - Oral Contraceptive and Serotonergic Brain Signaling	nan	UNKNOWN
PET Whole Body Distribution Studies Using [11C]CUMI	nan	COMPLETED
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Transcranial Alternating Current Stimulation (tACS) on Serotonin-1A Receptor in Depression	nan	UNKNOWN
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Imaging Serotonin 5HT1A Receptors in Patients With Major Depressive Disorder	nan	WITHDRAWN
Effects of Lurasidone on Left Ventricle Systolic Functions	nan	NOT_YET_RECRUITING
Trazodone and the Risk of Serious Adverse Events	nan	COMPLETED
Psychobiological Characterization of Depression in Hepatitis C	nan	UNKNOWN
Investigating Serotonin Signalling in IBD Patients	nan	RECRUITING
The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health	nan	COMPLETED
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder	nan	COMPLETED
Investigating the Neuropsychological Effects of 5-HT2a Antagonism	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a HTR5A binder may also engage these)

Protein	Name	Similarity
P30966	—	1.000	P30966 →
P35364	—	1.000	P35364 →
P35365	—	0.995	P35365 →
P79748	—	0.994	P79748 →
Q6XXX9	—	0.994	Q6XXX9 →
P47800	—	0.993	P47800 →
P52703	—	0.993	P52703 →
O70528	—	0.993	O70528 →
HTR1B	5-hydroxytryptamine receptor 1B	0.993	landscape →
P31387	—	0.993	P31387 →
Q5IS72	—	0.993	Q5IS72 →
Q6XXY0	—	0.992	Q6XXY0 →
P79250	—	0.992	P79250 →
P35404	—	0.992	P35404 →
HTR4	5-hydroxytryptamine receptor 4	0.992	landscape →
DRD3	D(3) dopamine receptor	0.992	landscape →
P97288	—	0.992	P97288 →
O42384	—	0.991	O42384 →
P56496	—	0.991	P56496 →
Q9N2B7	—	0.991	Q9N2B7 →
Q588Y6	—	0.990	Q588Y6 →
HTR1A	5-hydroxytryptamine receptor 1A	0.990	landscape →
O42385	—	0.990	O42385 →
Q91081	—	0.990	Q91081 →
Q0EAB5	—	0.990	Q0EAB5 →
P18901	—	0.990	P18901 →
P54833	—	0.990	P54833 →
Q6XXX8	—	0.989	Q6XXX8 →
Q9N297	—	0.989	Q9N297 →
Q8JG69	—	0.989	Q8JG69 →