Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.51 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.51 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.51 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11081340 | 1.00 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10849485 | 0.97 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL11081002 | 0.97 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10635641 | 0.85 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10635651 | 0.85 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10635636 | 0.85 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL11069563 | 0.83 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10850253 | 0.83 | ABCC9 (0.48) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10852038 | 0.83 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8LMNA | |
| SCHEMBL10852034 | 0.83 | ABCC9 (0.72) | ABCC9ABCC8KCNJ11KCNJ8LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126350-A1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1984-11-28 | — | — | EP | claimed |
| US-4629734-A | HYPOTENSIVE AGENTS | BEECHAM GROUP P.L.C. (GB) | 1986-12-16 | — | — | US | disclosed |
| EP-0126350-A1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1984-11-28 | — | — | EP | disclosed |