Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10851047 | 0.93 | MRGPRX4 (0.43) | MAOBMRGPRX4CYSLTR2CYSLTR1PDE10A | |
| SCHEMBL10853318 | 0.87 | MRGPRX4 (0.41) | MAOBMRGPRX4PDE10AFFAR1KCNH2 | |
| SCHEMBL10857601 | 0.86 | FFAR1 (0.42) | MAPTPDE10AFFAR1KCNH2 | |
| SCHEMBL10854791 | 0.84 | KCNH2 (0.40) | MAOBMRGPRX4CYSLTR2CYSLTR1MAPT | |
| SCHEMBL10854757 | 0.84 | MRGPRX4 (0.50) | MRGPRX4MAPTPDE10AFFAR1KCNH2 | |
| SCHEMBL10783493 | 0.80 | NR4A2 (0.55) | MAOBMRGPRX4NR4A2MAPTFFAR1 | |
| SCHEMBL10856859 | 0.79 | PDE10A (0.38) | MRGPRX4CYSLTR2CYSLTR1MAPTPDE10A | |
| SCHEMBL10855266 | 0.78 | MEN1 (0.45) | MAPTALDH1A1PDE10AFFAR1KCNH2 | |
| SCHEMBL10901479 | 0.77 | NR4A2 (0.52) | MAOBMRGPRX4NR4A2MAPTFFAR1 | |
| SCHEMBL11116230 | 0.77 | MAOB (0.39) | MAOBMRGPRX4NR4A2PDE10AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0113587-B1 | PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1986-12-03 | — | — | EP | claimed |
| US-4598080-A | NECROSIS, CARCINOSIS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1986-07-01 | — | — | US | claimed |
| US-4598080-A | NECROSIS, CARCINOSIS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1986-07-01 | — | — | US | disclosed |
| EP-0113587-A1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1984-07-18 | — | — | EP | disclosed |