Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10858144 | 0.83 | MAPT (0.35) | NPC1RAB9ACYSLTR2CYSLTR1SMN1; SMN2 | |
| SCHEMBL10854791 | 0.81 | KCNH2 (0.40) | PDE10AKCNH2NPC1RAB9ACYSLTR2 | |
| SCHEMBL10855266 | 0.81 | MEN1 (0.45) | PDE10AGRM5KCNH2MEN1KMT2A | |
| SCHEMBL10851047 | 0.81 | MRGPRX4 (0.43) | PDE10AKCNH2CYSLTR2CYSLTR1SMN1; SMN2 | |
| SCHEMBL10857601 | 0.81 | FFAR1 (0.42) | PDE10AGRM5KCNH2NPC1RAB9A | |
| SCHEMBL10854757 | 0.81 | MRGPRX4 (0.50) | PDE10AGRM5KCNH2NPC1RAB9A | |
| SCHEMBL10786833 | 0.81 | MAOB (0.44) | MEN1KMT2ALMNAMAPT | |
| SCHEMBL10854960 | 0.79 | MAOB (0.41) | PDE10AKCNH2CYSLTR2CYSLTR1MAPT | |
| SCHEMBL10853318 | 0.79 | MRGPRX4 (0.41) | PDE10AGRM5KCNH2ALOX5ALOX5AP | |
| SCHEMBL13232411 | 0.75 | KCNH2 (0.56) | PDE10AGRM5KCNH2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0113587-B1 | PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1986-12-03 | — | — | EP | claimed |
| US-4598080-A | NECROSIS, CARCINOSIS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1986-07-01 | — | — | US | claimed |
| EP-0113587-A1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1984-07-18 | — | — | EP | claimed |
| EP-0113587-B1 | PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1986-12-03 | — | — | EP | disclosed |
| US-4598080-A | NECROSIS, CARCINOSIS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1986-07-01 | — | — | US | disclosed |
| EP-0113587-A1 | Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them | Richter Gedeon Vegyészeti Gyár R.T. (HU) | 1984-07-18 | — | — | EP | disclosed |