Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10655218 | 0.88 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL12323976 | 0.88 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL1775216 | 0.86 | SMN1; SMN2 (0.82) | MEN1KMT2ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL11010135 | 0.86 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL4638870 | 0.85 | MEN1 (0.59) | MEN1KMT2AHSD17B10SMN1; SMN2ALDH1A1 | |
| SCHEMBL10654653 | 0.85 | MEN1 (0.64) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL14552522 | 0.84 | MEN1 (0.69) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL14552392 | 0.84 | MEN1 (0.66) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL14552420 | 0.83 | MEN1 (0.83) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL10926938 | 0.83 | MEN1 (0.65) | MEN1KMT2AHSD17B10SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4568687-A | THROMBOXANE SYNTHETASE TNZYME INHIBITORS; HYPOTENSIVE AGENTS, CARDIOTONIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0117462-A2 | N-(2-4-(1H-imidazol-1-yl)alkyl)arylamides | AMERICAN CYANAMID COMPANY (US) | 1984-09-05 | — | — | EP | disclosed |