Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.72 |
| ▸ | REN | P00797 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.72 |
| ▸ | F2 | P00734 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 1/20 | 0.72 |
| ▸ | LTA4H | P09960 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.72 |
| ▸ | PEPD | P12955 | 1/20 | 0.72 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.72 |
| ▸ | HTR2A | P28223 | 1/20 | 0.72 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.72 |
| ▸ | HRH1 | P35367 | 1/20 | 0.72 |
| ▸ | THPO | P40225 | 1/20 | 0.72 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.72 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19362588 | 1.00 | ACE (0.72) | ACERENKDM4EF2LMNA | |
| SCHEMBL10802283 | 1.00 | ACE (0.72) | ACERENKDM4EF2LMNA | |
| SCHEMBL21660967 | 1.00 | ACE (0.72) | ACERENKDM4EF2LMNA | |
| SCHEMBL6788721 | 0.87 | ACE (0.77) | ACERENKDM4EF2LMNA | |
| SCHEMBL6788727 | 0.87 | ACE (0.77) | ACERENKDM4EF2LMNA | |
| SCHEMBL6788835 | 0.87 | ACE (0.85) | ACERENKDM4EF2LMNA | |
| SCHEMBL12680174 | 0.85 | ACE (0.74) | ACERENKDM4EF2LMNA | |
| SCHEMBL29426304 | 0.85 | ACE (0.74) | ACERENKDM4EF2LMNA | |
| SCHEMBL15223628 | 0.85 | ACE (0.74) | ACERENKDM4EF2LMNA | |
| SCHEMBL19235752 | 0.85 | ACE (0.74) | ACERENKDM4EF2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0035336-B1 | NOVEL PROCESSES FOR PREPARING PROLINE DERIVATIVES AND ANALOGOUS COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 1986-04-09 | — | — | EP | disclosed |
| US-4578480-A | ANGIOTENSIN CONVERTING ENZYME INHUBITOR INTERMEDIATES | JOHN WYETH & BROTHER LIMITED (GB) | 1986-03-25 | — | — | US | disclosed |
| US-4506082-A | DEESTERIFICATION WITH TRIFLUOROACETIC ACID | JOHN WYETH & BROTHER LIMITED (GB) | 1985-03-19 | — | — | US | disclosed |
| US-4399144-A | HYPOTENSIVE AGENTS, ENZYME INHIBITOR | JOHN WYETH AND BROTHER LIMITED (GB) | 1983-08-16 | — | — | US | disclosed |
| US-4391752-A | Process for preparing 5H-pyrrolo[2,1-c]-[1,4]thiazepine-1,5-diones | JOHN WYETH AND BROTHER LIMITED (GB) | 1983-07-05 | — | — | US | disclosed |
| US-4349480-A | Process for preparing 1-(3-bromo-2-alkylpropanoyl-L-proline derivatives | JOHN WYETH & BROTHER LIMITED (GB) | 1982-09-14 | — | — | US | disclosed |
| US-4331673-A | HYPOTENSIVE, INTERMEDIATES TO CAPTOPRIL | JOHN WYETH & BROTHER LIMITED (GB) | 1982-05-25 | — | — | US | disclosed |
| EP-0035336-A2 | Novel processes for preparing proline derivatives and analogous compounds | JOHN WYETH & BROTHER LIMITED (GB) | 1981-09-09 | — | — | EP | disclosed |
| US-4181663-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1980-01-01 | — | — | US | disclosed |