Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10861492 | 0.85 | CCNE2 (0.34) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL10861251 | 0.82 | KMT2A (0.44) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL5124845 | 0.82 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL10860870 | 0.81 | MAPT (0.43) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL10857100 | 0.78 | MAPT (0.39) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL11101301 | 0.78 | CCNE2 (0.36) | CCNE2CCNE1CDK2 | |
| SCHEMBL10860127 | 0.77 | HPGD (0.38) | MAPTNPC1RAB9ASMN1; SMN2HTT | |
| SCHEMBL20925876 | 0.75 | HPGD (0.49) | MAPTNPC1RAB9ASMN1; SMN2CCNE2 | |
| SCHEMBL20912900 | 0.70 | PTPN2 (0.38) | MAPTNPC1RAB9ASMN1; SMN2ALOX15 | |
| SCHEMBL10857097 | 0.70 | KMT2A (0.51) | SMN1; SMN2HTTKDM4EALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4590203-A | Derivatives of thiophene-2-carboxylic acid and their pharmaceutically acceptable acid or base addition salts and use in treatment of conditions caused by thromboxane A2 | LAEVOSAN-GESELLSCHAFT M.B.H. & CO. KG (AT) | 1986-05-20 | — | — | US | disclosed |