Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.48 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | PLG | P00747 | 3/20 | 0.39 |
| ▸ | PLAT | P00750 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.39 |
| ▸ | TMPRSS15 | P98073 | 5/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 3/20 | 0.38 |
| ▸ | KLK8 | O60259 | 2/20 | 0.38 |
| ▸ | KLK4 | Q9Y5K2 | 2/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.38 |
| ▸ | KLK2 | P20151 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339823 | 0.88 | PLAU (0.52) | PLAUTMPRSS11DF2PLGPLAT | |
| SCHEMBL10858361 | 0.85 | PRSS1 (0.48) | PLAUF2PRSS1TMPRSS15F10 | |
| SCHEMBL10922460 | 0.77 | PLAU (0.54) | PLAUF2PLGPLATPRSS1 | |
| SCHEMBL7343617 | 0.77 | PLAU (0.50) | PLAUF2PRSS1F10ITGB3 | |
| SCHEMBL10936099 | 0.76 | PLAU (0.47) | PLAUF2PLGPLATPRSS1 | |
| SCHEMBL7339820 | 0.74 | FTO (0.56) | PLAUTMPRSS11DF2PLGPLAT | |
| SCHEMBL7345716 | 0.74 | PLAU (0.53) | PLAUF2PLGPLATPRSS1 | |
| SCHEMBL7339710 | 0.73 | PLAU (0.60) | PLAUF2PLGPLATPRSS1 | |
| SCHEMBL7341606 | 0.72 | PLAU (0.60) | PLAUF2PLGPLATPRSS1 | |
| SCHEMBL10917873 | 0.71 | PLAU (0.46) | PLAUF2PLGPLATPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4563527-A | INHIBITORS OF TRYPSIN, PLASMIN, KALLIKREIN, THROMBIN AND COMPLEMENT | TORII & CO., LTD. (JP) | 1986-01-07 | — | — | US | disclosed |