FTO — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL220211	1.00	10/20
SCHEMBL216815	0.82	10/20
Fluorescein (SCHEMBL336329)	0.81	10/20
SCHEMBL20095	0.69	10/20
SCHEMBL20833	0.67	10/20
SCHEMBL329252	0.67	10/20
SCHEMBL291009	0.66	10/20
SCHEMBL139173	0.65	10/20
SCHEMBL71426	0.64	10/20
SCHEMBL82165	0.63	10/20
SCHEMBL160107	0.62	10/20
SCHEMBL20832	0.60	10/20
SCHEMBL212438	0.60	10/20
SCHEMBL273427	0.59	10/20
SCHEMBL293820	0.59	10/20
SCHEMBL84112	0.59	10/20
SCHEMBL136169	0.56	10/20
SCHEMBL164316	0.56	10/20
SCHEMBL134733	0.56	10/20
SCHEMBL16544	0.55	10/20

Clinical trials — most relevant to FTO by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Weight Loss Study: Genetics and Response to Naltrexone/Bupropion	PHASE4	RECRUITING
Dopamine Action on Metabolism in Relation to Genotype	PHASE2	COMPLETED
The Role of FTO Gene Polymorphism and Insulin Preparation in Obesity in Children With Type 1 Diabetes Mellitus	nan	COMPLETED
Association Between the Change of the Genes With Hormones and Food Consumption of Obese	nan	COMPLETED
Balanced Nutritional Diet Intervention Among Obese Women	nan	COMPLETED
Effect of Exercise on Appetite, Gut Peptides and Butyrylcholinesterase Activity in Variants of the FTO Gene	nan	COMPLETED
Using the Epitranscriptome to Diagnose and Treat Gliomas	nan	RECRUITING
FTO Gene Variants and Diet in Obesity	nan	COMPLETED
Preference of Protein Intake and FTO rs1558902 Gene Polymorphism Among Women Obese	nan	COMPLETED
Individual Variability of Appetite Responses to a Standardised Meal	nan	COMPLETED
Effects of Gallotannins on the Gut Microbiome and How it Affects Inflammatory Markers Among Obese Individuals.	nan	ACTIVE_NOT_RECRUITING
Hydroxymethylation, Incident Type 2 Diabetes and Incident Obesity	nan	UNKNOWN
Expression of TET1 Gene in Acute Leukaemia	nan	UNKNOWN
Diet-Induced Changes in GEnetic Material	nan	RECRUITING
Effects of Exercise Intervention and Confounding Factors on Type II Diabetic Muscles	nan	COMPLETED
Dietary Protein Requirements on Unbalanced Diets	nan	COMPLETED
MyGeneMyDiet Trial for Weight Management	nan	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Magnetic Resonance Imaging in Obesity	nan	COMPLETED
Genetics in the Effect of Caffeine on Fat Oxidation	nan	COMPLETED
Nutrigenomics, Overweight/Obesity and Weight Management Trial (NOW Trial)	nan	UNKNOWN
Genetic Determinants and Clinical Consequences of Early-onset Severe Obesity	nan	UNKNOWN
Influence of Genetic and Physiological in Weight Loss	nan	COMPLETED
Human Faecal Microbiota in Type 2 Diabetes	nan	COMPLETED
Linking Obesity and Estrogen-responsive Genes in Endometrial Cancer	nan	COMPLETED
Impact of Weight Loss on the Human Sperm Epitranscriptome	nan	ACTIVE_NOT_RECRUITING
An Exploratory Clinical Trial to Generate Whole Blood Samples for Analysing Genetic Polymorphisms	nan	WITHDRAWN
Retrospective Evaluation of Melanocortin Receptor 4 Polymorphisms in Patients With GBM Treated With Radiochemotherapy	nan	COMPLETED
Investigation of the Genetic and Environmental Causes of Autism: a Multi-Center Study	nan	NOT_YET_RECRUITING
Genetic and Epigenetic Risk of T2D in the UAE	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a FTO binder may also engage these)

Protein	Name	Similarity
Q5R7X0	—	1.000	Q5R7X0 →
Q2A121	—	1.000	Q2A121 →
F1PLN3	—	1.000	F1PLN3 →
Q8BGW1	—	1.000	Q8BGW1 →
Q68F54	—	0.994	Q68F54 →
Q8R4Z9	—	0.986	Q8R4Z9 →
Q65945	—	0.985	Q65945 →
B5DE73	—	0.984	B5DE73 →
ALKBH1	Nucleic acid dioxygenase ALKBH1	0.983	landscape →
Q5XHF8	—	0.983	Q5XHF8 →
Q811U4	—	0.983	Q811U4 →
P87552	—	0.983	P87552 →
Q8IWA4	—	0.982	Q8IWA4 →
P12539	—	0.982	P12539 →
Q8NG08	—	0.982	Q8NG08 →
Q4R4D7	—	0.982	Q4R4D7 →
Q8C5W4	—	0.982	Q8C5W4 →
Q6DIR8	—	0.982	Q6DIR8 →
Q6NVF4	—	0.982	Q6NVF4 →
PADI2	Protein-arginine deiminase type-2	0.982	landscape →
Q6P1Y8	—	0.982	Q6P1Y8 →
WFS1	Wolframin	0.981	landscape →
Q5SNQ7	—	0.981	Q5SNQ7 →
Q86VS3	—	0.981	Q86VS3 →
O88480	—	0.981	O88480 →
P0CI65	—	0.981	P0CI65 →
F4HZK4	—	0.981	F4HZK4 →
Q93ZS1	—	0.981	Q93ZS1 →
Q62141	—	0.981	Q62141 →
KDM5D	Lysine-specific demethylase 5D	0.981	landscape →