SCHEMBL1086155

SCHEMBL1086155

CN[C@H]([C]=O)Cc1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 5/20 0.53
SIGMAR1 Q99720 4/20 0.53
SLC18A2 Q05940 1/20 0.53
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
CTSC P53634 4/20 0.42
SLC6A2 P23975 2/20 0.42
MAOA P21397 1/20 0.42
SLC6A4 P31645 1/20 0.42
SLC6A3 Q01959 1/20 0.42
CYP2A6 P11509 1/20 0.42
ADORA2A P29274 1/20 0.42
ADORA1 P30542 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1310109 1.00 TAAR1 (0.53) TAAR1SIGMAR1SLC18A2MEN1KMT2A
SCHEMBL6852331 1.00 TAAR1 (0.53) TAAR1SIGMAR1SLC18A2MEN1KMT2A
SCHEMBL1308859 0.82 CTSC (0.44) TAAR1SIGMAR1SLC18A2MEN1KMT2A
SCHEMBL1308857 0.82 CTSC (0.44) TAAR1SIGMAR1SLC18A2MEN1KMT2A
SCHEMBL6513822 0.82 CTSC (0.44) TAAR1SIGMAR1SLC18A2MEN1KMT2A
SCHEMBL2639452 0.81 TAAR1 (0.46) TAAR1SIGMAR1MEN1KMT2ASLC6A2
SCHEMBL8340029 0.81 SIGMAR1 (0.56) TAAR1SIGMAR1SLC18A2MEN1KMT2A
SCHEMBL9728414 0.81 SLC6A2 (0.46) TAAR1MEN1KMT2ACTSCSLC6A2
SCHEMBL9439379 0.81 SLC6A2 (0.46) TAAR1MEN1KMT2ACTSCSLC6A2
SCHEMBL7517353 0.81 TAAR1 (0.46) TAAR1SIGMAR1MEN1KMT2ASLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 188 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060194737-A1 Hepta-, octa-and nonapeptides having antiangiogenic activity HAVIV FORTUNA 2006-08-31 US claimed
US-7067490-B2 Hepta-, Octa-and nonapeptides having antiangiogenic activity ABBOTT LABORATORIES (US) 2006-06-27 US claimed
EP-1451210-A2 HEPTA-, OCTA- AND NONAPEPTIDES HAVING ANTIANGIOGENIC ACTIVITY Abbott Laboratories (US) 2004-09-01 EP claimed
US-6777535-B1 USEFUL FOR TREATING CONDITIONS WHICH ARISE OR ARE EXACERBATED BY ANGIOGENESIS ABBOTT LABORATORIES 2004-08-17 US claimed
US-6632795-B1 Treatment of cancer BASF AKTIENGESELLSCHAFT (DE) 2003-10-14 US claimed
US-20030109455-A1 HEPTA-, OCTA-and nonapeptides having antiangiogenic activity ABBVIE INC. 2003-06-12 US claimed
EP-0981358-B1 DOLASTATIN-15 DERIVATIVES IN COMBINATION WITH TAXANES BASF AG (DE) 2003-05-28 EP claimed
US-20030096758-A1 HEPTA-, OCTA- and nonapeptides having antiangiogenic activity ABBOTT LABORATORIES 2003-05-22 US claimed
WO-2003037268-A2 HEPTA-, OCTA- AND NONAPEPTIDES HAVING ANTIANGIOGENIC ACTIVITY ABBOTT LABORATORIES (US) 2003-05-08 WO claimed
EP-1242455-A1 N-ALKYLATED PEPTIDES HAVING ANTIANGIOGENIC ACTIVITY Abbott Laboratories (US) 2002-09-25 EP claimed
EP-0417454-A2 Reduced size LHRH analogs ABBOTT LABORATORIES (US) 1991-03-20 EP claimed
EP-0400065-A4 LHRH ANALOGS 1991-03-13 EP claimed
EP-0413209-A1 LHRH analogs TAP Pharmaceuticals Inc. (US) 1991-02-20 EP claimed
EP-0400065-A1 LHRH ANALOGS. ABBOTT LAB (US) 1990-12-05 EP claimed
EP-0390181-A2 Perylenequinone (UCN-1028D) derivatives KYOWA HAKKO KOGYO CO., LTD. (JP) 1990-10-03 EP claimed
WO-1989007450-A1 LHRH ANALOGS ABBOTT LABORATORIES (US) 1989-08-24 WO claimed
WO-1989007451-A1 REDUCED SIZE LHRH ANALOGS ABBOTT LABORATORIES (US) 1989-08-24 WO claimed
EP-0328089-A2 Reduced size LHRH analogs ABBOTT LABORATORIES (US) 1989-08-16 EP claimed
EP-0328090-A2 LHRH analogs ABBOTT LABORATORIES (US) 1989-08-16 EP claimed
EP-0008196-B1 PENTAPEPTIDES, PROCESSES FOR THEIR PREPARATION, INTERMEDIATES USED IN SUCH PROCESSES, USE IN PHARMACEUTICAL COMPOSITIONS AND COMPOSITIONS CONTAINING THEM AMERICAN HOME PRODUCTS CORPORATION (US) 1983-09-07 EP claimed