⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1996074 | 0.78 | — | — | |
| SCHEMBL10180025 | 0.75 | — | — | |
| SCHEMBL1532379 | 0.75 | — | — | |
| SCHEMBL13555426 | 0.73 | — | — | |
| SCHEMBL12226184 | 0.73 | — | — | |
| SCHEMBL25285279 | 0.73 | — | — | |
| SCHEMBL17191757 | 0.73 | — | — | |
| SCHEMBL5175757 | 0.71 | — | — | |
| SCHEMBL9076718 | 0.71 | — | — | |
| SCHEMBL2738465 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179671-A1 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-8557839-B2 | Fused ring azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20120225856-A1 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2012-09-06 | — | — | US | disclosed |
| US-8153820-B2 | Method for the production of N-substituted (3-dihalomethyl-1-methylpyrazol-4-yl) carboxamides | BASF SE (DE) | 2012-04-10 | — | — | US | disclosed |
| US-20110166110-A1 | Fused Ring Azadecalin Glucocorticoid Receptor Modulators | CORCEPT THERAPEUTICS, INC. (US) | 2011-07-07 | — | — | US | disclosed |
| US-7928237-B2 | Fused ring azadecalin glucocorticoid receptor modulators | CORCEPT THERAPEUTICS, INC. (US) | 2011-04-19 | — | — | US | disclosed |
| US-20100174094-A1 | Method for the Production of N-Substituted (3-Dihalomethyl-1-Methyl-Pyrazole-4-yl) Carboxamides | BASF SE (DE) | 2010-07-08 | — | — | US | disclosed |
| EP-1735308-B1 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS INC (US) | 2008-09-10 | — | — | EP | disclosed |
| US-20070281928-A1 | Fused Ring Azadecalin Glucocorticoid Receptor Modulators | CORCEPT THERAPEUTICS INCORPORATED | 2007-12-06 | — | — | US | disclosed |
| EP-1735308-A1 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | Corcept Therapeutics, Inc. (US) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005087769-A1 | FUSED RING AZADECALIN GLUCOCORTICOID RECEPTOR MODULATORS | CORCEPT THERAPEUTICS, INC. (US) | 2005-09-22 | — | — | WO | disclosed |