SCHEMBL10863602

SCHEMBL10863602

C[C@@H](O)[C@@H]1C(=O)N2C(C(=O)OSc3ccccc3)=C(Sc3ccccc3)[C@H](C)[C@@H]12

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.40
PTGS1 P23219 1/20 0.40
PDE4A P27815 1/20 0.40
ABCC2 Q92887 1/20 0.38
CACNA1C Q13936 1/20 0.37
ELANE P08246 7/20 0.37
FAP Q12884 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10863599 1.00 ESR1 (0.40) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL10863222 1.00 ESR1 (0.40) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL10863213 1.00 ESR1 (0.40) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL9836121 0.87 PTGS1 (0.50) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL10614146 0.87 PTGS1 (0.50) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL8530735 0.87 PTGS1 (0.50) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL9220178 0.87 PTGS1 (0.50) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL9220172 0.87 PTGS1 (0.50) ESR1PTGS1PDE4AABCC2CACNA1C
SCHEMBL9216219 0.79 ELANE (0.46) ELANEFAP
SCHEMBL10612514 0.79 ELANE (0.46) ELANEFAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0188816-A1 Novel beta-lactams and their production SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1986-07-30 EP disclosed