Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.33 |
| ▸ | LIPE | Q05469 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10614146 | 1.00 | PTGS1 (0.50) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL9220178 | 1.00 | PTGS1 (0.50) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL9836121 | 1.00 | PTGS1 (0.50) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL9220172 | 1.00 | PTGS1 (0.50) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL10863222 | 0.87 | ESR1 (0.40) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL10863599 | 0.87 | ESR1 (0.40) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL10863213 | 0.87 | ESR1 (0.40) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL10863602 | 0.87 | ESR1 (0.40) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL9696350 | 0.86 | ESR1 (0.47) | PTGS1ESR1PDE4ACACNA1CABCC2 | |
| SCHEMBL22166268 | 0.84 | ESR1 (0.46) | PTGS1ESR1PDE4ACACNA1CABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0504612-B1 | Novel 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them | AMERICAN CYANAMID CO (US) | 1998-01-21 | — | — | EP | disclosed |
| US-5656753-A | 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them | AMERICAN CYANAMID COMPANY (US) | 1997-08-12 | — | — | US | disclosed |
| US-5371215-A | 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them | AMERICAN CYANAMID COMPANY (US) | 1994-12-06 | — | — | US | disclosed |
| US-5189158-A | 4-SUBSTITUTED AZETIDINONES AS PRECURSORS TO 2-SUBSTITUTED-3-CARBOXY CARBAPENEM ANTIBIOTICS AND A METHOD OF PRODUCING THEM | AMERICAN CYANAMID COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| EP-0504612-A2 | Novel 4-substituted azetidinones as precursors to 2-substituted-3-carboxy carbapenem antibiotics and a method of producing them | AMERICAN CYANAMID COMPANY (US) | 1992-09-23 | — | — | EP | disclosed |