Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 19/20 | 0.52 |
| ▸ | PGA5 | P0DJD9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10867999 | 0.95 | REN (0.52) | REN | |
| SCHEMBL10825119 | 0.89 | REN (0.58) | REN | |
| SCHEMBL10869206 | 0.87 | REN (0.59) | REN | |
| SCHEMBL10725721 | 0.87 | REN (0.59) | REN | |
| SCHEMBL10725717 | 0.87 | REN (0.59) | REN | |
| SCHEMBL10825253 | 0.86 | REN (0.57) | REN | |
| SCHEMBL10825102 | 0.86 | REN (0.57) | REN | |
| SCHEMBL10825108 | 0.86 | REN (0.57) | REN | |
| SCHEMBL8904372 | 0.85 | REN (0.61) | REN | |
| SCHEMBL10766573 | 0.83 | REN (0.56) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0181071-A2 | Amino acid ester and amide renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1986-05-14 | — | — | EP | claimed |
| EP-0181071-A2 | Amino acid ester and amide renin inhibitors | E.R. Squibb & Sons, Inc. (US) | 1986-05-14 | — | — | EP | disclosed |