Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 5/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.60 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.60 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.60 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 1/20 | 0.60 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.60 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.60 |
| ▸ | HRH2 | P25021 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10867551 | 0.90 | CHRM3 (0.60) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL10868462 | 0.89 | CHRM3 (0.59) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL10869423 | 0.88 | CHRM3 (0.63) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL13721373 | 0.88 | CHRM3 (0.60) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL4428968 | 0.88 | CHRM3 (0.56) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL4428975 | 0.88 | CHRM3 (0.56) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL10868180 | 0.87 | DRD2 (0.57) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL13590341 | 0.86 | CHRM3 (0.61) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL13592297 | 0.86 | CHRM3 (0.61) | CHRM3CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL13590079 | 0.86 | CHRM3 (0.61) | CHRM3CHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0178946-A2 | 1-(Aminoalkyl)-alpha, alpha-diaryl pyrrolidine-piperidine- and homopiperidine- acetamides and acetonitriles | A.H. ROBINS COMPANY, INCORPORATED (US) | 1986-04-23 | — | — | EP | disclosed |