Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL209656 | 1.00 | — | — | |
| Bicarbonate SCHEMBL28168658 | 1.00 | CA1 (0.71) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL28282052 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28064756 | 0.94 | — | — | |
| Bicarbonate SCHEMBL6013375 | 0.94 | — | — | |
| Bicarbonate SCHEMBL5572362 | 0.94 | — | — | |
| Bicarbonate SCHEMBL853 | 0.93 | — | — | |
| Bicarbonate SCHEMBL5458673 | 0.93 | CA1 (0.83) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL2718215 | 0.93 | CA1 (0.83) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL5458669 | 0.93 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909166-A1 | PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | Symed Labs Limited (IN) | 2015-08-26 | — | — | EP | claimed |
| WO-2014064706-A1 | PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2014-05-01 | — | — | WO | claimed |
| CN-107108782-B | Terminal-modified soluble polyfunctional vinyl aromatic co-polymer and its application | 日铁化学材料株式会社 | 2019-12-03 | — | — | CN | disclosed |
| CN-106458881-B | Carotenoid derivatives, its pharmaceutically acceptable salt or its pharmaceutically acceptable esters or amides | 阿斯塔制药有限公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-107217301-B | Compound lithium fluoroborate potassium and lithium fluoroborate nonlinear optical crystal of potassium and preparation method and purposes | 中国科学院新疆理化技术研究所 | 2019-04-12 | — | — | CN | disclosed |
| CN-107847989-A | Clean-in-place method and system and combinations thereof | 艺康美国股份有限公司 | 2018-03-27 | — | — | CN | disclosed |
| CN-107400083-A | A kind of preparation method of 3 [2 (3 chlorphenyl) ethyl] 2 pyridine carbonitriles | 四川大学 | 2017-11-28 | — | — | CN | disclosed |
| CN-107217301-A | Compound lithium fluoroborate potassium and lithium fluoroborate nonlinear optical crystal of potassium and preparation method and purposes | 中国科学院新疆理化技术研究所 | 2017-09-29 | — | — | CN | disclosed |
| CN-107108782-A | Terminal-modified soluble polyfunctional vinyl aromatic co-polymer, curable resin composition and use its light guide wave duct | 新日铁住金化学株式会社 | 2017-08-29 | — | — | CN | disclosed |
| CN-103069319-B | Fiber waveguide forms with resin combination, the fiber waveguide formation resin film using it and uses their fiber waveguide | 日立化成株式会社 | 2017-03-01 | — | — | CN | disclosed |
| CN-104364000-B | Integration of pressure swing adsorption and power plants for CO 2 capture/utilization and N2 production | 埃克森美孚研究工程公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106458881-A | Carotenoid derivative, pharmaceutically acceptable salt thereof, and pharmaceutically acceptable ester or amide thereof | 富士化学工业株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-105899534-A | Fc region variants with modified FCRN and maintained protein A binding properties | 豪夫迈·罗氏有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-105873948-A | Fc region variants with modified FCRN binding properties | 豪夫迈·罗氏有限公司 | 2016-08-17 | — | — | CN | disclosed |
| EP-0175587-A2 | Process for treating chemically stabilized, adhesive activated polyester material, polyester material treatedby the process and an improved finish composition | CELANESE CORPORATION (US) | 1986-03-26 | — | — | EP | disclosed |