SCHEMBL10876901

SCHEMBL10876901

CN(CCO)C(=O)c1cncc(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 1/20 0.50
KMT2A Q03164 2/20 0.41
MAPT P10636 1/20 0.40
CHRNB2 P17787 1/20 0.39
CHRNA4 P43681 1/20 0.39
HDAC4 P56524 1/20 0.38
TLR9 Q9NR96 1/20 0.37
TLR8 Q9NR97 1/20 0.37
TLR7 Q9NYK1 1/20 0.37
PDK2 Q15119 2/20 0.37
SLC6A7 Q99884 1/20 0.37
SMYD3 Q9H7B4 1/20 0.37
HRH4 Q9H3N8 2/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
PYGL P06737 1/20 0.36
MKNK1 Q9BUB5 1/20 0.36
MKNK2 Q9HBH9 1/20 0.36
CDK4 P11802 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7662074 0.89 KMT2A (0.45) HCAR2KMT2AMAPTHDAC4TLR9
SCHEMBL30444680 0.88 HCAR2 (0.50) HCAR2KMT2ACHRNB2CHRNA4HDAC4
SCHEMBL17297343 0.83 HCAR2 (0.51) HCAR2KMT2AMAPTHDAC4TLR9
SCHEMBL10873474 0.82 HPGD (0.48) HCAR2KMT2AMAPTSMYD3KDM4E
SCHEMBL9525657 0.81 KMT2A (0.58) HCAR2KMT2AMAPTKDM4E
SCHEMBL10876070 0.81 HCAR2 (0.46) HCAR2KDM4EALDH1A1PYGL
SCHEMBL14754870 0.80 KMT2A (0.45) KMT2AMAPTHDAC4TLR9TLR8
SCHEMBL827059 0.80 HCAR2 (0.60) HCAR2KMT2ACHRNB2CHRNA4SMYD3
SCHEMBL19156384 0.79 TLR9 (0.41) KMT2ACHRNB2CHRNA4HDAC4TLR9
SCHEMBL14752155 0.79 ESRRG (0.41) KMT2AHDAC4TLR9TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0198311-A2 Nicotin amides and their use as fungicidal agents F. HOFFMANN-LA ROCHE AG (CH) 1986-10-22 EP disclosed