Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10878639 | 0.85 | MEN1 (0.45) | MAPTPTPN1GSK3BKMT2AMEN1 | |
| SCHEMBL10879320 | 0.84 | TSHR (0.44) | MAPTALOX15HSD17B10GSK3BKMT2A | |
| SCHEMBL10878524 | 0.82 | KMT2A (0.46) | MAPTALOX15HSD17B10KMT2AMEN1 | |
| SCHEMBL11628185 | 0.77 | ALOX15 (0.46) | ALOX15HSD17B10KMT2AMEN1L3MBTL1 | |
| SCHEMBL10877046 | 0.77 | KDM4E (0.43) | MAPTPTPN1GSK3BKMT2AMEN1 | |
| SCHEMBL10879352 | 0.74 | CA9 (0.45) | MAPTALDH1A1NCOA3 | |
| SCHEMBL10509753 | 0.74 | ALOX15 (0.50) | MAPTALOX15HSD17B10GSK3BKMT2A | |
| SCHEMBL10880531 | 0.73 | KMT2A (0.39) | PTPN1GSK3BKMT2AMEN1ALDH1A1 | |
| SCHEMBL10876563 | 0.72 | AKR1B1 (0.46) | PTPN1KMT2AMEN1MAP3K5POLB | |
| SCHEMBL19134405 | 0.72 | POLB (0.46) | MAPTKMT2AMEN1MAP3K5POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045165-B1 | RHODANINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, AND ALDOSE REDUCTASE INHIBITORS CONTAINING SUCH DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1986-03-12 | — | — | EP | claimed |
| US-4446143-A | Rhodanine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-05-01 | — | — | US | claimed |
| EP-0045165-A1 | Rhodanine derivatives, a process for their preparation, and aldose reductase inhibitors containing such derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-02-03 | — | — | EP | claimed |
| EP-0045165-B1 | RHODANINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION, AND ALDOSE REDUCTASE INHIBITORS CONTAINING SUCH DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 1986-03-12 | — | — | EP | disclosed |
| US-4446143-A | Rhodanine derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0045165-A1 | Rhodanine derivatives, a process for their preparation, and aldose reductase inhibitors containing such derivatives | ONO PHARMACEUTICAL CO., LTD. (JP) | 1982-02-03 | — | — | EP | disclosed |