Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PDE4A | P27815 | 9/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10877917 | 0.83 | HPGD (0.50) | HPGDALDH1A1MAPTPDE3BPDE3A | |
| SCHEMBL10879697 | 0.83 | PDE3B (0.49) | HPGDALDH1A1PDE3BPDE3APDE4A | |
| SCHEMBL10877366 | 0.83 | PDE3B (0.49) | HPGDALDH1A1MAPTPDE3BPDE3A | |
| SCHEMBL10876464 | 0.83 | PDE3B (0.51) | HPGDALDH1A1MAPTPDE3BPDE3A | |
| SCHEMBL10876292 | 0.81 | PDE3B (0.72) | HPGDPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10876140 | 0.80 | PDE3B (0.46) | HPGDPDE3BPDE3APDE4APDE4B | |
| SCHEMBL10876017 | 0.77 | TSHR (0.54) | ALDH1A1MAPTPDE3BPDE3ATSHR | |
| SCHEMBL11175098 | 0.77 | PDE4A (0.63) | HPGDALDH1A1MAPTPDE3BPDE3A | |
| SCHEMBL10875000 | 0.74 | MEN1 (0.48) | HPGDALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL10915560 | 0.73 | PDE3B (0.47) | HPGDMAPTPDE3BPDE3ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065165-B1 | 5-OXYMETHYL-4-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| US-4526981-A | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0065165-A1 | 5-Oxymethyl-4-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-24 | — | — | EP | disclosed |