Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.43 |
| ▸ | LPAR2 | Q9HBW0 | 5/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.43 |
| ▸ | NAAA | Q02083 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28188990 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL14097235 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL27716434 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL10407022 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL11705765 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL14874595 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL1864784 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL29065831 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL21114427 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 | |
| SCHEMBL525805 | 0.97 | CA12 (0.48) | CA12CA1CA2CA9DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0084708-B1 | POLYSACCHARIDE OR PROTEIN ARTICLES WITH INCLUDED NON-AQUEOUS LIQUID | UNILEVER PLC (GB) | 1986-01-22 | — | — | EP | disclosed |
| US-4471871-A | Packaged dry-to-the-touch article and method of packaging the article | LEVER BROTHERS COMPANY (US) | 1984-09-18 | — | — | US | disclosed |
| EP-0084708-A1 | Polysaccharide or protein articles with included non-aqueous liquid | UNILEVER PLC (GB) | 1983-08-03 | — | — | EP | disclosed |