Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of P-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GFER | P55789 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Nitrophenol SCHEMBL10879323 | 0.89 | MAPT (0.46) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL28636238 | 0.88 | HSD17B10 (0.54) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL28573812 | 0.86 | HSD17B10 (0.52) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL11205589 | 0.86 | TSHR (0.53) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL27528063 | 0.84 | ALDH1A1 (0.59) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL1115712 | 0.83 | HSD17B10 (0.58) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL11048842 | 0.83 | CES1 (0.58) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL29806213 | 0.83 | CES1 (0.58) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL1839 | 0.83 | CES1 (0.58) | MAPTALDH1A1KMT2AMEN1GAA | |
| P-Nitrophenol SCHEMBL29016446 | 0.82 | ALDH1A1 (0.56) | MAPTALDH1A1KMT2AMEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0054989-B1 | ELECTROLYTIC CAPACITOR | Koninklijke Philips Electronics N.V. (NL) | 1986-02-19 | — | — | EP | disclosed |
| EP-0054989-A1 | Electrolytic capacitor | Koninklijke Philips Electronics N.V. (NL) | 1982-06-30 | — | — | EP | disclosed |