Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.37 |
| ▸ | GYS1 | P13807 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10881010 | 1.00 | TP53 (0.44) | TP53MDM2ACEKMT2AP2RX7 | |
| SCHEMBL18204610 | 0.83 | PLA2G10 (0.42) | ACEKMT2AP2RX7GYS1MEN1 | |
| SCHEMBL17951050 | 0.83 | PLA2G10 (0.42) | ACEKMT2AP2RX7GYS1MEN1 | |
| SCHEMBL31694803 | 0.82 | ACE (0.43) | ACEKMT2AP2RX7MEN1ALDH1A1 | |
| SCHEMBL6694973 | 0.81 | ACE (0.44) | ACEKMT2AP2RX7MEN1ALDH1A1 | |
| SCHEMBL24750149 | 0.81 | TP53 (0.40) | TP53MDM2KMT2AP2RX7BRD4 | |
| SCHEMBL9831208 | 0.80 | TP53 (0.45) | TP53MDM2KMT2AALDH1A1BRD4 | |
| SCHEMBL29150853 | 0.80 | ACE (0.43) | ACEKMT2AP2RX7GYS1MEN1 | |
| SCHEMBL6705720 | 0.80 | ACE (0.43) | ACEKMT2AP2RX7GYS1MEN1 | |
| SCHEMBL2583832 | 0.79 | P2RX7 (0.48) | ACEKMT2AP2RX7GYS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080283-B1 | N-CARBOXYALKYLPROLINE-CONTAINING TRIPEPTIDES | SMITHKLINE BECKMAN CORPORATION (US) | 1986-01-29 | — | — | EP | disclosed |
| US-4456594-A | N-Carboxyalkylproline-containing tripeptides | SMITHKLINE BECKMAN CORPORATION (US) | 1984-06-26 | — | — | US | disclosed |
| EP-0080283-A1 | N-carboxyalkylproline-containing tripeptides | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |