Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.49 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10885329 | 0.92 | ACE (0.52) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL11191259 | 0.88 | ACE (0.55) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL11196591 | 0.87 | ACE (0.52) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL11195194 | 0.87 | ACE (0.52) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL649163 | 0.85 | ACE (0.58) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL10882833 | 0.85 | ACE (0.46) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL10882970 | 0.85 | ACE (0.50) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL10882819 | 0.85 | ACE (0.51) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL10882786 | 0.84 | ACE (0.46) | ACEDPP8DPP4DPP9DPP7 | |
| SCHEMBL10883461 | 0.84 | ACE (0.44) | ACEDPP8DPP4DPP9DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079522-B1 | N-CARBOXYMETHYL(AMIDINO)LYSYL-PROLINE ANTIHYPERTENSIVE AGENTS | MERCK & CO. INC. (US) | 1986-05-07 | — | — | EP | disclosed |
| EP-0079522-A1 | N-Carboxymethyl(amidino)lysyl-proline antihypertensive agents | MERCK & CO. INC. (US) | 1983-05-25 | — | — | EP | disclosed |