Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 13/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | PGR | P06401 | 5/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7574132 | 0.93 | HIF1A (0.73) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL10603555 | 0.93 | HIF1A (0.65) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL11110241 | 0.90 | HIF1A (0.62) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| Hydrochloric Acid SCHEMBL11053488 | 0.89 | HIF1A (0.61) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL770501 | 0.89 | HIF1A (0.72) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL11108120 | 0.89 | HIF1A (0.61) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL10883182 | 0.89 | HIF1A (0.59) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| Hydrochloric Acid SCHEMBL11058103 | 0.88 | HIF1A (0.60) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL10527431 | 0.88 | HIF1A (0.62) | HIF1ASMN1; SMN2MAPTPOLBGAA | |
| SCHEMBL10923487 | 0.88 | HIF1A (0.58) | HIF1ASMN1; SMN2MAPTPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106453-B1 | 21-HYDROXYCORTICOSTEROID ESTERS, AND COMPOSITIONS CONTAINING THEM | THE UPJOHN COMPANY (US) | 1986-10-22 | — | — | EP | disclosed |
| US-4456602-A | SOLUTION STABLE ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1984-06-26 | — | — | US | disclosed |
| EP-0106453-A1 | 21-Hydroxycorticosteroid esters, and compositions containing them | THE UPJOHN COMPANY (US) | 1984-04-25 | — | — | EP | disclosed |