Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 13/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.60 |
| ▸ | PGR | P06401 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.56 |
| ▸ | AR | P10275 | 2/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | FNTA | P49354 | 1/20 | 0.55 |
| ▸ | FNTB | P49356 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10603555 | 0.94 | HIF1A (0.65) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| SCHEMBL871152 | 0.92 | HIF1A (0.76) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| SCHEMBL10527431 | 0.91 | HIF1A (0.62) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| SCHEMBL10700873 | 0.91 | HIF1A (0.64) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| SCHEMBL7574132 | 0.90 | HIF1A (0.73) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| SCHEMBL7094755 | 0.90 | HIF1A (0.60) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| SCHEMBL10606730 | 0.89 | HIF1A (0.58) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| SCHEMBL13232 | 0.89 | HIF1A (0.74) | HIF1ASMN1; SMN2LMNANFKB1PMP22 | |
| Succinic Acid SCHEMBL7600416 | 0.89 | HIF1A (0.66) | HIF1ASMN1; SMN2LMNANFKB1NR3C1 | |
| SCHEMBL10883093 | 0.89 | HIF1A (0.63) | HIF1ASMN1; SMN2LMNANFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 457 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117618349-A | Inflammatory microenvironment response type polymer micelle combining CDK inhibitor and anti-inflammatory drug as well as preparation method and application thereof | 宁夏医科大学 | 2024-03-01 | — | — | CN | claimed |
| US-11813279-B2 | Compositions for cancer therapy and methods | AIM IMMUNOTECH INC. (US) | 2023-11-14 | — | — | US | claimed |
| CN-114010606-A | Freeze-dried preparation containing methylprednisolone sodium succinate and preparation method thereof | 莱默(北京)药业科技有限公司 | 2022-02-08 | — | — | CN | claimed |
| CN-109485686-B | Method for improving content of key intermediate 6 beta in methylprednisolone succinate impurity synthesis | 重庆华邦胜凯制药有限公司 | 2021-08-27 | — | — | CN | claimed |
| CN-111150709-B | Methylprednisolone sodium succinate for injection and preparation method thereof | 天津梅花生物医药科技有限公司 | 2021-06-22 | — | — | CN | claimed |
| CN-112702993-A | Pharmaceutical compositions suitable for joint delivery and their use in the treatment of joint pain | TLC生物医药公司 | 2021-04-23 | — | — | CN | claimed |
| CN-109678919-B | Preparation method of methylprednisolone succinate impurity | 重庆华邦胜凯制药有限公司 | 2021-04-13 | — | — | CN | claimed |
| CN-112469420-A | Method for reducing complications of steroids in joints | 台湾微脂体股份有限公司 | 2021-03-09 | — | — | CN | claimed |
| CN-108498468-B | Methylprednisolone sodium succinate for injection | 福安药业集团湖北人民制药有限公司 | 2020-12-18 | — | — | CN | claimed |
| CN-111991347-A | Methylprednisolone sodium succinate for injection and preparation method thereof | 岳阳环宇药业有限公司 | 2020-11-27 | — | — | CN | claimed |
| WO-2011039511-A2 | AGENTS, USES AND METHODS | CYTOGUIDE A/S (DK) | 2011-04-07 | — | — | WO | claimed |
| EP-1694298-B1 | METHOD FOR SELECTING CATIONIC OR ANIONIC LIPOSOMES FOR TREATMENT OF A MUCOSA MEMBRANE, AND KIT COMPRISING THE SAME | YISSUM RES DEV CO (IL) | 2010-06-09 | — | — | EP | claimed |
| US-20070212403-A1 | Method for Selecting Cationic or Anionic Liposomes for Treatment of a Mucosa Membrane, and Kit Comprising the Same | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 2007-09-13 | — | — | US | claimed |
| EP-1656178-A1 | METHOD AND DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX | Alza Corporation (US) | 2006-05-17 | — | — | EP | claimed |
| WO-2005016441-A1 | METHOD AND DEVICE FOR ENHANCING TRANSDERMAL AGENT FLUX | ALZA CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2003082251-A2 | THE EFFERVESCENT PHARMACEUTICAL DOSAGE FORM OF ESTERS AND ESTER SALTS OF 6 α METHYLPREDNISOLONE SUCCINATE, PROCEDURE FOR ITS OBTAINING AND APPLICATION | HEMOFARM KONCERN A.D. PHARMACEUTICAL AND CHEMICAL INDUSTRY (YU) | 2003-10-09 | — | — | WO | claimed |
| US-5279543-A | Device for iontophoretic non-invasive sampling or delivery of substances | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-01-18 | — | — | US | claimed |
| EP-0120557-B1 | 21-HYDROXYCORTICOSTEROID ESTERS, AND COMPOSITIONS CONTAINING THEM | THE UPJOHN COMPANY (US) | 1989-06-07 | — | — | EP | claimed |
| EP-0120557-A2 | 21-Hydroxycorticosteroid esters, and compositions containing them | THE UPJOHN COMPANY (US) | 1984-10-03 | — | — | EP | claimed |
| US-4472392-A | Sulfonate containing ester prodrugs of corticosteroids | THE UPJOHN COMPANY (US) | 1984-09-18 | — | — | US | claimed |