Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10847556 | 0.87 | RXFP1 (0.51) | TP53RXFP1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL10847842 | 0.81 | RXFP1 (0.65) | TP53RXFP1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL10848061 | 0.79 | — | — | |
| SCHEMBL10885287 | 0.73 | TP53 (0.56) | TP53RXFP1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL404420 | 0.73 | MAPT (0.65) | TP53RXFP1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL11099211 | 0.73 | TP53 (0.61) | TP53RXFP1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL10848030 | 0.71 | TP53 (0.59) | TP53RXFP1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL405269 | 0.71 | HRH4 (0.60) | TP53RXFP1MAPTSMN1; SMN2KMT2A | |
| SCHEMBL10846907 | 0.71 | TP53 (0.61) | TP53RXFP1MAPTKMT2AMEN1 | |
| SCHEMBL12224096 | 0.69 | MAPT (0.54) | TP53RXFP1MAPTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0107455-B1 | TRIAZOLOQUINOXALINES AS ANTIDEPRESSANTS AND ANTIFATIGUE AGENTS | PFIZER INC. (US) | 1986-07-09 | — | — | EP | disclosed |
| US-4547501-A | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents | PFIZER INC. (US) | 1985-10-15 | — | — | US | disclosed |
| US-4495187-A | Method of using [1,2,4]triazolo[4,3-a]quinoxaline-4-amine derivatives as antidepressant and antifatigue agents | PFIZER INC. (US) | 1985-01-22 | — | — | US | disclosed |